Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study
Frontiers in Psychiatry · Ocak 2025
YÖKSİS Kayıtları
Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study
Frontiers in Psychiatry · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSTAFA ESAD TEZCAN →
Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study
Frontiers in Psychiatry · 2025 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiFrontiers in Psychiatry
Yayın TarihiOcak 2025
Cilt / Sayfa16
Scopus ID2-s2.0-85219525741
Erişim🔓 Açık Erişim
Özet
Introduction: The aim of this study is to investigate whether arginine and its metabolites can be an endophenotype for bipolar disorder (BD) and to evaluate the role of arginine metabolites and neurocognitive function levels in unaffected healthy children of parents diagnosed with BD in cognitive impairment. Methods: The study included 37 healthy children of parents diagnosed with BD Type I as the high-risk group and 36 healthy children of parents without any psychiatric disorders as the control group. The arginine, n-monomethyl-l-arginine acetate (L-NMMA), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), citrulline, homoarginine, ornithine serum levels, and nitric oxide synthase (NOS) activity level of both groups were compared. Results: The study found that in the high-risk group, ADMA, SDMA, and ornithine levels were significantly higher compared to the controls, while citrulline and NOS activity level were significantly lower in the high-risk group compared to the controls. All neurocognitive performances of the high-risk group were considered statistically significantly worse compared to controls. The impairment in neurocognitive functions in the high-risk group was found to be correlated with ADMA, L-NMMA, citrulline, homoarginine, ornithine levels, and NOS activity level. Discussion: These findings highlight a potential link between arginine metabolism and executive dysfunction in individuals at high risk for BD. Further longitudinal studies are essential to fully understand the complex interactions between these factors.
Yazarlar (11)
1
Gökçeçiçek Arıcı Sağlıyan
2
Fatih Hilmi Çetin
3
Fikret Akyürek
4
Oguzhan Tok
5
Özlem Çiçek Zekey
6
Mustafa Esad Tezcan
ORCID: 0000-0001-8362-1934
7
Bilal Sağlıyan
ORCID: 0000-0002-6563-3058
8
Serhat Türkoğlu
9
Halit Necmi Uçar
ORCID: 0000-0002-2706-7454
10
Bahadır Öztürk
11
Kürşat Altınbaş
Anahtar Kelimeler
arginine
asymmetric dimethylarginine (ADMA)
bipolar disorder
children
high risk
neurocognitive function
offspring
Kurumlar
Diamind Mental Academy
Konya Turkey
Konya City Hospital
Konya Turkey
Private Practitioner
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Sivas Numune Hospital
Sivas Turkey