Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Investigation of the sensitivity of human A549 cells to paclitaxel and sesquiterpene lactone alantolactone via apoptosis induction
Naunyn Schmiedeberg S Archives of Pharmacology · Ağustos 2025
YÖKSİS Kayıtları
Investigation of the sensitivity of human A549 cells to paclitaxel and sesquiterpene lactone alantolactone via apoptosis induction
Naunyn-Schmiedeberg's Archives of Pharmacology · 2025 SCI-Expanded
ÖĞRETİM GÖREVLİSİ İREM BAYAR →
Makale Bilgileri
DergiNaunyn Schmiedeberg S Archives of Pharmacology
Yayın TarihiAğustos 2025
Cilt / Sayfa398 · 10625-10633
Scopus ID2-s2.0-85218998407
Erişim🔓 Açık Erişim
Özet
Alantolactone (ALA), a sesquiterpene lactone compound obtained from Inula helenium root, is known to have anticancer activity in many types of cancer. Paclitaxel (PAX) is an effective first-line chemotherapeutic drug and is widely used in the treatment of lung cancer. The in vitro anticancer efficacy of combined treatment of ALA with PAX was investigated in the A549 human lung cancer cell line. The results show that ALA potentiated the effect of PAX-induced growth restriction and apoptosis in A549 cells. The combined administration more effectively decreased the Bcl-2 expression and increased Bax gene expression in cells compared to ALA or PAX alone. Also, co-treatment of ALA and PAX caused apoptotic nuclear formations. Additionally, coadministration increased the caspase-3 and caspase-9 levels more than PAX or ALA alone. The increase in NF-κB gene expression levels suggests that an NF-κB-independent apoptotic trigger mechanism operates in cells. Together, the present in vitro findings suggest that ALA may contribute as a potential therapeutic strategy in the treatment of lung cancer.
Yazarlar (5)
1
İrem Bayar
2
Yalcin Erzurumlu
ORCID: 0000-0001-6835-4436
3
Senem Akkoc
ORCID: 0000-0002-1260-9425
4
Zafer Bulut
5
Mehmet Nizamlioǧlu
Anahtar Kelimeler
A549
Alantolactone
Apoptosis
Lung cancer
Paclitaxel
Kurumlar
Bahçeşehir Üniversitesi
Istanbul Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
SDU University
Kaskelen Kazakhstan
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime