Scopus
YÖKSİS DOI Eşleşti
SJR Q4
Microstructural Changes in Normal-Appearing White Matter in Pediatric X-Linked Adrenoleukodystrophy: A Diffusion Tensor Imaging Study
Journal of Pediatric Neurology · Ekim 2023
YÖKSİS Kayıtları
Microstructural Changes in Normal-Appearing White Matter in Pediatric X-Linked Adrenoleukodystrophy: A Diffusion Tensor Imaging Study
Georg Thieme Verlag KG · 2023 ESCI
Doç. Dr. HAKAN CEBECİ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Microstructural Changes in Normal-Appearing White Matter in Pediatric X-Linked Adrenoleukodystrophy: A Diffusion Tensor Imaging Study
2023 ISSN: 1304-2580 ESCI
Doç. Dr. HAKAN CEBECİ →
Makale Bilgileri
ISSN13042580
Yayın TarihiEkim 2023
Cilt / Sayfa21 · 347-351
Scopus ID2-s2.0-85174858218
Özet
Objective: Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique that provides quantitative diffusion data of water molecules in tissue. Usage of DTI in pediatric X-linked adrenoleukodystrophy (X-ALD) may adjunct earlier detection of brain involvement. This study aimed to analyze the normal-appearing white matter in pediatric patients with X-ALD using DTI. Materials and Methods: A retrospective database search was performed. Children with genetically diagnosed X-ALDs with a reportedly normal brain MRI between January 2010 and September 2021 were included. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and apparent diffusion coefficient were serially measured in 8 regions of the brain, and these measurements were compared with those in control patients. Results: The study group included 21 X-ALD patients and 11 control patients. The mean age was 6.64 ± 5.14 years. FA values of the genu and body of the corpus callosum were significantly lower in the ALD group than controls. There was also a statistically significant difference in FA, AD, and RD values of cerebellar white matter in the two groups. Conclusion: There is evidence of white matter damage on DTI in X-ALD patients with the normal-appearing white matter on conventional MRI sequences. The inclusion of DTI in routine MRI examinations of X-ALD patients may provide additional insight into possible white matter damage in that population.
Yazarlar (6)
1
Hakan Cebeci
2
Jeffrey Rykken
3
Frederick Ott
ORCID: 0000-0003-1468-4725
4
Mark Folkertsma
5
Yasemin Koksel
6
Mehmet Gencturk
Anahtar Kelimeler
brain
diffusion tensor imaging
magnetic resonance
X-linked adrenoleukodystrophy
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Minnesota Medical Center, Fairview
Minneapolis United States
Scimago Dergi (ISSN Eşleşmesi)
Journal of Pediatric Neurology
Q4
SJR Skoru0,140
H-Index21
YayıncıGeorg Thieme Verlag
ÜlkeGermany
Neurology (clinical) (Q4)
Pediatrics, Perinatology and Child Health (Q4)