Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Evaluation of neopterin, oxidative stress, and immune system in silicosis
Turkish Journal of Biochemistry · Haziran 2025
YÖKSİS Kayıtları
Evaluation of neopterin, oxidative stress, and immune system in silicosis
Turkish Journal of Biochemistry · 2025 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Is median value of Double Screening Test regional?
2015 ISSN: 0250-4685 SCI-Expanded Q4
Doç. Dr. RAMAZAN KOCABAŞ →
Calculation of measurement uncertainty of biochemical parameters
2015 ISSN: 02504685 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
The effects of grape seed extract against toxicity of benzene on liver and kidney tissues of albino mice biochemical evaluation
2015 ISSN: 0250-4685 SCI-Expanded
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Analysis of trace elements in epileptic patients
2015 ISSN: 0250-4685 SCI-Expanded
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Serum Paraoxonase Levels and Oxidative Stress in Patients with Scleroderma
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Analysis of Trace Elements in Epileptic Patients
2015 ISSN: 0250-4685 SCI-Expanded
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The Analytical Performance of The C Petide and Insuline Test
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Procalcitonin Levels in Inflammatory Disease
2015 ISSN: 0250-4685 SCI-Expanded
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Comparison of Routine Biochemical and Hormonal Values of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
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Comparison Of MPV WBC and Neutrophil Lymphocyte Ratio of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSEYİN YILMAZ →
Influence of Pinealectomy on Hemogram Parameters of Rats Applied to Sepsis Model
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Meme Kanser Hücrelerinin Fluıdıgm Dynamıc Array Kullanılarak Kantitatif miRNA Ekspresyaon Analizi
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
25 OH D3 ve 1 25 OH 2 D3 ün MCF 7 Meme Kanser Hücre Hattının Proliferasyonu Üzerine Kıyaslanması
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
The effect of single dose administration of nandrolone decanoate on plasma irisin adropin leptin levelsTek doz nandrolon dekonat uygulamasının plazma irisin adropin leptin düzeylerine etkisi
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. SEYFULLAH HALİLOĞLU →
Makale Bilgileri
ISSN02504685
Yayın TarihiHaziran 2025
Cilt / Sayfa50 · 370-379
Scopus ID2-s2.0-86000301560
Erişim🔓 Açık Erişim
Özet
The onset and advancement of silicosis are intricately linked to immune system activation and oxidative stress. We aimed to examine whether occupational silica exposure induces alterations in neopterin levels, the immune system, or the oxidant/antioxidant system. Fifty-Two healthy individuals, 47 workers with silica exposure who did not develop the disease, and 71 silicosis patients were included in the study, totaling 170 participants. Neopterin was measured in serum and urine. Chromatographic analysis of neopterin level was performed with Thermo Ultimate 3000 ultra-high-performance liquid chromatography system. Tumor necrosis factor alpha (TNF-α), interferon-gamma (IFN-γ), fibroblast growth factor (FGF), interleukin (IL)-1α, IL-1β, 8-hydroxy-2-deoxyguanosine (8-OH-dG), glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were measured in serum. Immune and oxidative stress parameters were measured by spectrophotometric and spectrofluorometric methods. Serum neopterin levels were significantly different between the study groups, while urinary neopterin levels were not. Serum neopterin levels were significantly decreased in the silicosis group compared to the exposure and non-exposed group groups. TNF-α, IFN-γ, FGF, IL-1α, 8-OH-dG, and GR increased with silica exposure, while SOD and GPx decreased. Serum neopterin, IL-1α, GR, age, and forced expired volume (FEV1%) were found to be risk factors for silicosis development. A negative correlation existed between neopterin levels, TNF-α, and overall exposure duration. Neopterin is applicable in the diagnosis and monitoring of oxidative stress and alterations in the immune system associated with silicosis. Thus, it can ensure that preventive measures are taken at an early stage.
Yazarlar (5)
1
Recai Ergün
2
Dilek Ergün
3
Esin Özkan
4
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
5
M. K. Korez
ORCID: 0000-0001-9524-6115
Anahtar Kelimeler
antioxidants
immune parameters
neopterin
occupational silica exposure
oxidative stress
silicosis
Kurumlar
Onyedi Eylul University
Balikesir Turkey
Rush University Medical Center
Chicago United States
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Biochemistry
Q3
OA
SJR Skoru0,232
H-Index26
YayıncıWalter de Gruyter GmbH
ÜlkeGermany
Biochemistry (medical) (Q3)
Biochemistry (Q4)
Clinical Biochemistry (Q4)
Molecular Biology (Q4)
Metrikler
3
Atıf
5
Yazar
6
Anahtar Kelime