Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Ultrastructural changes in the common carotid artery in terms of age and gender-related in Rat model
Revista Cientifica De La Facultad De Veterinaria · Ocak 2025
YÖKSİS Kayıtları
Ultrastructural changes in the common carotid artery in terms of age and gender-related in Rat model
Revista Científica de la Facultad de Ciencias Veterinarias · 2025 SCI-Expanded
Dr. Öğr. Üyesi NEJAT ÜNLÜKAL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded Q4
Arş. Gör. ZEYNEP ÇELİK KENAR →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
Determination of Embryotoxic effects of Atipamezole using in ovo model
2023 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
Evaluation of tumor necrosis Factor Alpha, Interferon Gamma, Procalcitonin and Neopterin levels in Brucella seropositive cattle
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZLEM DERİNBAY EKİCİ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. AHMET LEVENT BAŞ →
Determination of the embryotoxic effect of Metronidazole using an in ovo model
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 CABI
Prof. Dr. OĞUZHAN AVCI →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. NERMİN IŞIK USLU →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. AHMET LEVENT BAŞ →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ZAFER SAYIN →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ASLI BALEVİ →
Morphometric investigation of the effects of Azoxymethane, Diallyl disulfide and corn oil use on humerus and femur development in rats
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ALİ USLU →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ENDER ERDOĞAN →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Pathological and biochemical investigation of the effects of Silybum marianum against Methomyl damage in broiler liver
2024 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN YONAR →
Makale Bilgileri
ISSN07982259
Yayın TarihiOcak 2025
Cilt / Sayfa35 · 1-8
Scopus ID2-s2.0-85219277359
Erişim🔓 Açık Erişim
Özet
Sex-related differences were investigated in ultrastructural modifications that occur with ageing in the rat carotid artery in the study. As ageing impacts every system and organ within the human body, it also impacts the circulatory system. The circulatory system serves various functions in the body such as nourishing organs and tissues, oxygenating and eliminating toxic substances. A condition like atherosclerosis or thrombosis in the circulatory system results in permanent harm to structures like the central nervous system, heart and even fatality. Although the pathologies observed in the vessels are commonly attributed to the generation of atheromas, it has been recognised in recent years that changes in the tunica intima and tunica media lead to impaired vascular function without the formation of atheromas. Despite the long-standing belief that women have a advantage in age-related cardiovascular diseases, there has been no ultrastructural examination to support this theory. We explored the sex-related discrepancies in the ultrastructural modifications produced by aging in the carotid artery. A total of 28 Sprague-Dawley rats, 14 males and 14 females, were planned to be used in the study. Of these 28 rats, 4 females and 4 males was constitute the control group. The rats in the control group was approximately 10 weeks old, and the rats in the experimental group, which was represent the aged group, was 19 weeks old. All animals in the study were anaesthetised and then sacrificed by removal of the heart. The right and left common carotid arteries were removed from the sacrificed animals. Collected vessels prepared for Transmission Electron Microscopy (TEM) examination. For each animal, at least four TEM images were taken from four different sections from the same block. As a result, the impact of vascular ageing manifested as apoptosis and age-related dysfunction in endothelial cells, thickening of the subendothelial layer, elastin deterioration, collagen deposition in the matrix, and degradation of the internal elastic lamina. Notably, vascular degeneration is more severe in men than in women. It is clear that the endothelium is subject to accumulated damage with age. We believe that the dissimilarity between males and females is attributed to the estrogen's proliferative and antiinflammatory impact.
Yazarlar (1)
1
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
Anahtar Kelimeler
Ageing
electron microscopy
endothelium
genderdependent difference
ultrastructural
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Revista Cientifica de la Facultad de Veterinaria
Q4
OA
SJR Skoru0,138
H-Index16
YayıncıUniversidad del Zulia, Facultad de Ciencias Veterinarias
ÜlkeVenezuela
Animal Science and Zoology (Q4)
Food Science (Q4)
Immunology and Microbiology (miscellaneous) (Q4)
Veterinary (miscellaneous) (Q4)