Scopus
🔓 Açık Erişim
The experıance of tertıary center for adult granulosa cell tumor: whıch factors predıct survival?
Journal of Ovarian Research · Aralık 2024
Makale Bilgileri
DergiJournal of Ovarian Research
Yayın TarihiAralık 2024
Cilt / Sayfa17
Scopus ID2-s2.0-85196321275
Erişim🔓 Açık Erişim
Özet
Background: This retrospective study aims to evaluate the clinical course and long-term outcomes of patients diagnosed with adult granulosa cell tumors (AGCT). Methods: The study analyzed a cohort of 112 AGCT patients with a median follow-up of 87 months. Data regarding disease-free survival (DFS), overall survival (OS), recurrence rates, and prognostic factors were collected and analyzed. Surgical interventions, including lymphadenectomy and cytoreductive surgery, were assessed for their impact on outcomes. Results: The study revealed favorable long-term outcomes, with a 5-year DFS of 85% and a 10-year DFS of 83%. Additionally, a 5-year OS of 100% and a 10-year OS of 96% were observed. Recurrence occurred in 13.4% of cases, with advanced stage and positive peritoneal cytology identified as independent poor prognostic factors for DFS. Lymph node involvement was rare, and routine lymphadenectomy did not improve outcomes. Conservative surgery showed comparable DFS rates to definitive surgery in early-stage disease. However, cytoreductive surgery was crucial for advanced and recurrent tumors, with complete tumor resection enhancing survival outcomes. Conclusion: The study underscores the importance of vigilant follow-up and individualized treatment strategies for AGCT patients. Despite the retrospective nature of the analysis, the substantial patient cohort and meticulous surgical interventions contribute valuable insights into AGCT management. Prospective multicenter studies are warranted to further elucidate prognostic factors and optimize treatment approaches for this rare malignancy.
Yazarlar (6)
1
Mustafa Şahin
2
Tufan Arslanca
3
Yeşim Özkaya Uçar
4
Gülşah Tiryaki Güner
5
İlker Selçuk
6
Hakan Raşit Yalçın
Anahtar Kelimeler
Adult granulosa cell tumors
Cytoreductive surgery
Prognostic factors
Recurrent tumors
Kurumlar
Universiteler Mahallesi
Ankara Turkey