Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E2and Interleukin-1β: A 6-month randomized controlled clinical trial
Nigerian Journal of Clinical Practice · Mayıs 2018
YÖKSİS Kayıtları
Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E2 and Interleukin-1β: A 6-month randomized controlled clinical trial
Nigerian Journal of Clinical Practice · 2018 SCI-Expanded
Prof. Dr. SEYFULLAH HALİLOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of different modes of erbium yttrium aluminum garnet laser on shear bond strength to dentin
2016 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. MURAT SELİM BOTSALI →
Fluoride release/recharging ability and bond strength of glass ionomer cements to sound and caries-affected dentin
2017 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. MURAT SELİM BOTSALI →
Effect of saliva decontamination procedures on shear bond strength of a one-step adhesive system
2017 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. HAYRİYE ESRA ÜLKER →
Evaluation of teeth development in unilateral cleft lip and palate patients in mixed dentition by using medical image control systems.
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. MURAT SELİM BOTSALI →
Effect of different modes of erbium:yttrium aluminum garnet laser on shear bond strength to dentin
2017 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. MURAT SELİM BOTSALI →
Shear bond strength of a novel porcelain repair system for different computer aided design/ computer assisted manufacturing ceramic materials
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. NECLA DEMİR →
THE EFFICIENCY OF DIFFERENT IRRIGATION SOLUTIONS AND TECHNIQUES FOR THE REMOVAL OF TRIPLE ANTIBIOTIC PASTE FROM SIMULATED IMMATURE ROOT CANALS
2018 ISSN: 1119-3077 SCI-Expanded Q4
Doç. Dr. AHMET AKTI →
Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E2 and Interleukin-1β: A 6-month randomized controlled clinical trial
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. SEYFULLAH HALİLOĞLU →
Efficacy of Using Erbium, Chromium‑Doped:Yttrium ScandiumGallium Garnet Laser‑Treated Dentine in a Dentine Barrier Test Device
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. HAYRİYE ESRA ÜLKER →
Accuracy of the Demirjian, Willems and Cameriere Methods of Estimating Dental Age on Turkish children
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. FÜSUN YAŞAR →
The effects of smoking cessation on visceral adiposity index levels
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. KAMİLE MARAKOĞLU →
Glucose Pump test can be Used to measure blood flow rate of native arteriovenous Fistula in Chronic Hemodialysis
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. LÜTFULLAH ALTINTEPE →
The effect of different irrigation protocols on elastic modulus of dentine and biomechanics of single-rooted premolar tooth: A nano-indentation and finite element analysis study
2019 ISSN: 1119-3077 SCI-Expanded Q4
Prof. Dr. OĞUZ ERASLAN →
A randomized study to evaluate post-dural puncture headache after cesarean section: Comparison with median and paramedian approaches
2019 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. MEHMET SARGIN →
Glucose Pump Test Can Be Used to Measure Blood Flow Rate of Native Arteriovenous Fistula in Chronic Hemodialysis
2018 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. YASEMİN COŞKUN YAVUZ →
A randomized study to evaluate post-dural puncture headache after cesarean section: Comparison with median and paramedian approaches
2019 ISSN: 1119-3077 SCI-Expanded
Doç. Dr. MEHMET SELÇUK ULUER →
The effect of the education model on the levels of state/continuous anxiety and self-efficacy of midwifery students
2020 ISSN: 1119-3077 SCI-Expanded Q4
Dr. Öğr. Üyesi EBRU BARIŞ →
The effect of kangaroo care on maternal attachment in preterm infants
2020 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. SİBEL KÜÇÜKOĞLU →
Effects of Artificial Aging on the Bond Strengths of Universal Dental
Adhesives
2020 ISSN: 1119-3077 SCI
Prof. Dr. ALİ RIZA ÇETİN →
Clinical evaluation of bulk-fill resins and glass ionomer restorative materials: A 1-year follow-up randomized clinical trial in children
2020 ISSN: 1119-3077 SCI-Expanded
Prof. Dr. GÜL TOSUN →
Makale Bilgileri
ISSN11193077
Yayın TarihiMayıs 2018
Cilt / Sayfa21 · 658-666
Scopus ID2-s2.0-85046802472
Erişim🔓 Açık Erişim
Özet
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while the adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) in the gingival crevicular fluid (GCF) of individuals with periodontitis. Materials and Methods: The study protocol was approved by the Ethics Committee (2000/071). Forty-one individuals with chronic periodontitis (33 men, 8 women) were divided into two groups (test and control) after initial periodontal therapy. During this 6-month, randomized, double-blind, placebo-controlled study, test (n = 28) and control (n = 13) groups were administered a cyclic regimen of DP (50 mg, twice daily) or placebo. Clinical measurements and GCF sample collections were made at baseline, 2, 4, and 6 months. GCF levels of PGE2and IL-1β were determined using enzyme immunoassay and enzyme-linked immunoassay kits, respectively. Results: At baseline, no significant differences existed between groups for plaque indices, gingival indices, bleeding on probing, probing depth (PD), or attachment levels (P > 0.05). Compared with the control group, cyclic regimen in the test group suppressed increased levels of PGE2found in GCF at the end of the study (P < 0.05). Significant differences for PD and relative attachment gain were also noted in favor of the test group (P < 0.05). Conclusions: These results suggest that a cyclic regimen of DP may be efficacious in the management of chronic periodontitis in adults.
Yazarlar (6)
1
Bahar Füsun Oduncuoğlu
2
Nezahat Arzu Kayar
ORCID: 0000-0002-2325-2900
3
S. Haliloglu
4
B. Serpek
5
Tamer Ataoglu
6
Nilgun Ozlem Alptekin
Anahtar Kelimeler
Anti-inflammatory agents
cytokines
gingival crevicular fluid
nonsurgical therapy
periodontitis
Kurumlar
Antalya Dental Health Center
Antakya Turkey
Başkent Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Nigerian Journal of Clinical Practice
Q3
SJR Skoru0,273
H-Index39
YayıncıWolters Kluwer Medknow Publications
ÜlkeNigeria
Medicine (miscellaneous) (Q3)
Metrikler
12
Atıf
6
Yazar
5
Anahtar Kelime