Scopus
YÖKSİS Eşleşti
Systemic treatment with alpha-tocopherol and/or sodium selenite decreases the progression of experimental periodontitis
Clinical Oral Investigations · Mayıs 2021
YÖKSİS Kayıtları
Systemic treatment with alpha-tocopherol and/or sodium selenite decreases the progression of experimental periodontitis.
Clinical Oral Investigations · 2020 SCI-Expanded
PROFESÖR SEYFULLAH HALİLOĞLU →
Systemic treatment with alpha-tocopherol and/or sodium selenite decreases the progression of experimental periodontitis
Clinical Oral Investigations · 2021 SCI-Expanded
PROFESÖR SEYFULLAH HALİLOĞLU →
Makale Bilgileri
DergiClinical Oral Investigations
Yayın TarihiMayıs 2021
Cilt / Sayfa25 · 2677-2688
Scopus ID2-s2.0-85091689342
Özet
Objective: To investigate the effects of sodium selenite (Se) and/or α-tocopherol (αT) applications on the alveolar bone loss (ABL), the number of gingival collagen fibers, inducible nitric oxide synthase (iNOS)+ and CD95+ cell numbers, and serum cytokine concentrations in experimental periodontitis in rats. Materials and methods: Forty Sprague Dawley rats were divided into four groups of ten as follows: group A: Se group, group B: αT group, group C: Se and αT combined group, and group D: control group (intraperitoneal (IP) saline injection applied). Using the image analysis method in the connective tissue under the connective epithelium, the numbers of iNOS, CD95 positive cells, and collagen fibers were counted. ELISA kits were used to test the concentrations of serum interleukin (IL)-1β, IL-6, and IL-4. Results: The combination of Se and αT (group C) suppressed ABL compared with the control group (group D) (P < 0.05). In group A (Se), the number of iNOS+ cells was smaller than in group D (P < 0.05). Conclusion: Se has been concluded to inhibit inflammation of the gum due to iNOS. Se and αT can have a remarkable important role in preventing alveolar bone loss, and particularly in combination. Clinical relevance: Se and/or αT application may be useful in preventing the destruction of periodontal tissue and treatment of periodontal disease.
Yazarlar (6)
1
Nurgül Bas
2
Nezahat Arzu Kayar
ORCID: 0000-0002-2325-2900
3
Z. Füsun Baba
4
Mustafa Avunduk
5
S. Haliloglu
6
Nilgun Ozlem Alptekin
Anahtar Kelimeler
Animal model
CD95
Experimental periodontitis
IL-1β
IL-4
IL-6
iNOS
Sodium selenite
α-Tocopherol
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Başkent Üniversitesi
Ankara Turkey
International Hospital Istanbul
Istanbul Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Metrikler
11
Atıf
6
Yazar
9
Anahtar Kelime