Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Can preoperative neopterin levels predict acute kidney injury in patients undergoing on-pump cardiac surgery?
Turkish Journal of Biochemistry · Ekim 2023
YÖKSİS Kayıtları
Can preoperative neopterin levels predict acute kidney injury in patients undergoing on-pump cardiac surgery?
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ HAKAN AKBAYRAK →
Can preoperative neopterin levels predict acute kidney injury in patients undergoing on-pump cardiac surgery?
TÜRK BİYOKİMYA DERGİSİ - TURKISH JOURNAL OF BICHEMISTRY · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ HAKAN AKBAYRAK →
Can preoperative neopterin levels predict acute kidney injury in patients undergoing on-pump cardiac surgery?
Turkish Journal of Biochemistry · 2023 SCI-Expanded
DOÇENT ATİLLA ORHAN →
Can preoperative neopterin levels predict acute kidney injury in patients undergoing on-pump cardiac surgery?
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi · 2023 SCI-Expanded
DOÇENT ÖMER FARUK ÇİÇEK →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiEkim 2023
Cilt / Sayfa48 · 531-540
Scopus ID2-s2.0-85176369774
Erişim🔓 Açık Erişim
Özet
Objectives: The aim of this study was to investigate the potential of preoperative neopterin levels as a predictive marker for postoperative acute kidney injury (AKI) in patients undergoing on-pump cardiac surgery, in addition to other potential risk factors. Methods: This observational study included 91 patients who underwent elective cardiac surgery under cardiopulmonary bypass. Of these, 35 patients (38.46 %) experienced AKI following surgery, as outlined by the Kidney Disease Improving Global Outcomes (KDIGO) standards. The study participants were divided into two groups depending on whether they had developed AKI after the surgery or not. The study compared two groups and utilized logistic regression analysis to evaluate potential predictors. A receiver operating characteristic (ROC) analysis was conducted to determine the ability of preoperative neopterin levels to predict the occurrence of AKI. Results: A comparison of the baseline demographic, clinical, laboratory, and echocardiographic characteristics was conducted between patients who suffered from AKI and those who did not. The multivariate analysis demonstrated that EuroSCORE II (OR, 4.525; 95 % CI, 1.29-15.87; p=0.019), X-clamp time (OR, 1.157; 95% CI, 1.01-1.326; p=0.035), and neopterin levels (OR, 22.952; 95 % CI, 3.14-167.763; p=0.002) were independently predicted the post-cardiac surgery AKI. ROC analysis identified a cut-off value of 9.65 nmol/L, which had a sensitivity of 91.4 % and a specificity of 91.1 % (area under the curve, 0.98; 95 % CI, 0.958-1; p<0.001). Conclusions: Our study emphasizes the potential of preoperative neopterin levels, EuroSCORE II, and X-clamp time as independent predictors of postoperative AKI, even in milder cases, in individuals undergoing on-pump cardiac surgery.
Yazarlar (6)
1
Ömer Faruk Çiçek
ORCID: 0000-0002-4675-3273
2
Fikret Akyürek
3
Hakan Akbayrak
4
Atilla Orhan
ORCID: 0000-0003-0110-3290
5
Eyüp Cihan Kaya
ORCID: 0000-0001-7836-1576
6
Mustafa Büyükateş
Anahtar Kelimeler
acute renal injury
cardiopulmonary bypass
neopterin
on-pump cardiac surgery
postoperative complication
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
5
Anahtar Kelime