Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis
Pediatrics International · Ağustos 2015
YÖKSİS Kayıtları
Total antioxidant and total oxidant states, and serum paraoxonase-1 inneonatal sepsis
Pediatrics International · 2015 SCI-Expanded
Dr. Öğr. Üyesi SAİME SÜNDÜS UYGUN →
Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis
Pediatrics International · 2015 SCI-Expanded
Doç. Dr. MURAT KONAK →
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2007 ISSN: 1328-8067 EBSCO
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Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis
2015 ISSN: 13288067 SCI-Expanded
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Two Outbreaks Due to ESBL Producing Klebsiella pneumoniae in A Neonatal Intensive Care Unit
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Makale Bilgileri
Dergi
Pediatrics International
ISSN13288067
Yayın TarihiAğustos 2015
Cilt / Sayfa57 · 608-613
Scopus ID2-s2.0-84940475437
Özet
Background Paraoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. Methods A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. Results In the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). Conclusion Low serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.
Yazarlar (10)
1
Ali Annagür
2
Rahmi Örs
3
Huseyin Altunhan
4
Sevil Kurban
5
Sabahattin Ertuʇrul
6
Murat Konak
7
Saime Sundus Uygun
8
S. Pekcan
9
Ekrem Erbay
10
Idris Mehmetoʇlu
Anahtar Kelimeler
neonatal sepsis
oxidative stress index
paraoxonase-1
total antioxidant state
total oxidant state
Kurumlar
Abant Izzet Baysal University, Faculty of Medicine
Bolu Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pediatrics International
Q3
SJR Skoru0,350
H-Index79
YayıncıJohn Wiley and Sons Inc
ÜlkeUnited States
Pediatrics, Perinatology and Child Health (Q3)
Metrikler
21
Atıf
10
Yazar
5
Anahtar Kelime