Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
European Journal of Pediatrics · Mayıs 2022
YÖKSİS Kayıtları
Epidemiologic and clinical characteristics of neonates with late‑onset
COVID‑19: 1‑year data of Turkish Neonatal Society
European Journal of Pediatrics · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
Makale Bilgileri
DergiEuropean Journal of Pediatrics
Yayın TarihiMayıs 2022
Cilt / Sayfa181 · 1933-1942
Scopus ID2-s2.0-85123408502
Erişim🔓 Açık Erişim
Özet
The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5–28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17–21.71), tachypnea (OR: 26.5, 95% CI: 9.59–73.19), and chest retractions (OR: 27.5, 95% CI: 5.96–126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course. Trial registration: ClinicalTrials.gov identifier: NCT04401540.What is Known:• Neonatal cases of COVID-19 infection are mainly reported as perinatal COVID-19 cases.• Neonates with perinatal transmission have a mild course and favorable prognosis.What is New:• Among symptomatic neonates with late-onset COVID-19 infection, fever was the most common symptom, and almost one quarter of hospitalized cases needed some type of respiratory support. Myocarditis was the most common complication.• The presence of cough, tachypnea, retractions, and a PT above 14 s were associated with an increased risk of severe COVID-19.
Yazarlar (53)
1
Ilke Mungan Akin
ORCID: 0000-0002-3677-1582
2
Mehmet Kenan Kanburoglu
3
Cuneyt Tayman
4
Mehmet Yekta Oncel
5
Timucin Imdadoglu
6
Mustafa Dilek
7
Akan Yaman
8
Fatma Narter
9
Ilkay Er
10
Hasan Kahveci
11
Ömer Erdeve
12
Esin Koc
13
Eren Yildiz
14
Nuriye Aslı Melekoglu
15
Emel Okulu
16
Handan Hakyemez Toptan
17
Ozge Surmeli
18
Emrah Can
19
Fatma Hilal Yılmaz
20
Hilal Ozkan
21
Ibrahim Caner
22
Serdar Cömert
23
Saime Sundus Uygun
24
Sinem Akbay
25
Asli Memisoglu
26
Ayse Anik
27
Baran Cengiz Arcagok
28
Belma S. Karagol
29
Mehmet Ates
30
Muhammet Bulut
31
Mustafa Ali Akin
32
Nihat Demir
33
Ramazan Ozdemir
34
Sema Arayici
35
Sebnem Kader
36
Adil Umut Zubarioglu
37
Ahmet Oktem
38
Ali Bulbul
39
Berna Hekimoglu
40
Emel Ataoglu
41
Demet Orhan Baser
42
Emine Esin Yalinbas
43
Ebru Yalin Imamoglu
44
Ferda Ozlu
45
Leyla Bilgin
46
Melike Kefeli
47
Meltem Koyuncu Arslan
48
Selahattin Akar
49
Handan Bezirganoglu
50
Senol Bozdag
51
Resat Gurpinar
52
Nukhet Aladag Ciftdemir
53
Ozmert Ma Ozdemir
Anahtar Kelimeler
COVID-19
Newborn
Postnatal
SARS-CoV-2
Kurumlar
Acıbadem Mehmet Ali Aydınlar Üniversitesi
Istanbul Turkey
Adiyaman Üniversitesi
Adiyaman Turkey
Ankara Üniversitesi
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Batman Maternity and Children's Hospital
Batman Turkey
Bolu Abant İzzet Baysal Üniversitesi
Bolu Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Ege Üniversitesi
Izmir Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Giresun Üniversitesi
Giresun Turkey
Inönü Üniversitesi
Malatya Turkey
Istanbul Medeniyet University
Istanbul Turkey
İstanbul Tıp Fakültesi
Istanbul Turkey
Izmir Democracy University
Izmir Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kahramanmaraş Necip Fazıl City Hospital
Kahramanmaras Turkey
Karadeniz Technical University
Trabzon Turkey
Kartal Dr. Lütfi Kırdar City Hospital
Istanbul Türkiye
Kastamonu University
Kastamonu Turkey
Kocaeli Üniversitesi
İzmit Turkey
Konya Dr Ali Kemal Berivanli Obstetrics and Children’s Hospital
Konya Turkey
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
Malatya Turgut Ozal University
Malatya Turkey
Manisa City Hospital
Manisa Turkey
Marmara Üniversitesi Tip Fakültesi
Istanbul Turkey
Nişantaşı Üniversitesi
Istanbul Turkey
Okan Üniversitesi
Tuzla Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Ozel Esencan Hospital
Istanbul Turkey
Pamukkale Üniversitesi Tip Fakültesi
Denizli Turkey
Recep Tayyip Erdogan University
Rize Turkey
Sakarya Üniversitesi
Serdivan Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Trakya University, Faculty of Medicine
Edirne Turkey
University of Health Sciences
Istanbul Turkey
Yeni Yüzyıl Üniversitesi
Istanbul Turkey
Metrikler
21
Atıf
53
Yazar
4
Anahtar Kelime