Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy
PLoS ONE · Aralık 2023
YÖKSİS Kayıtları
An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy
Public Library of Science (PLoS) · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
Makale Bilgileri
DergiPLoS ONE
Yayın TarihiAralık 2023
Cilt / Sayfa18
Scopus ID2-s2.0-85179770987
Erişim🔓 Açık Erişim
Özet
Background Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants ≥36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This study aims to determine the incidence of HIE in our country, to assess the TH management in infants with HIE, and present short-term outcomes of these infants. Methods The Turkish Hypoxic Ischemic Encephalopathy Online Registry database was established for this multicenter, prospective, observational, nationally-based cohort study to evaluate the data of infants born at ≥34 weeks GA who displayed evidence of neonatal encephalopathy (NE) between March, 2020 and April 2022. Results The incidence of HIE among infants born at ≥36 weeks GA (n = 965) was 2.13 per 1000 live births (517:242440), and accounting for 1.55% (965:62062) of all neonatal intensive care unit admissions. The rates of mild, moderate and severe HIE were 25.5% (n = 246), 58.9% (n = 568), and 15.6% (n = 151), respectively. Infants with severe HIE had higher rates of abnormal magnetic resonance imaging (MRI) findings, and mortality (p<0.001). No significant difference in mortality and abnormal MRI results was found according to the time of TH initiation (<3 h, 3-6 h and >6 h) (p>0.05). TH was administered to 85 (34.5%) infants with mild HIE, and of those born of 34-35 weeks of GA, 67.4% (n = 31) received TH. A total of 58 (6%) deaths were reported with a higher mortality rate in infants born at 34-35 weeks of GA (OR 3.941, 95% Cl 1.446-10.7422, p = 0.007). Conclusion The incidence of HIE remained similar over time with a reduction in mortality rate. The timing of TH initiation, whether <3 or 3-6 h, did not result in lower occurrences of brain lesions on MRI or mortality. An increasing number of infants with mild HIE and late preterm infants with HIE are receiving TH; however, the indications for TH require further clarification. Longer follow- up studies are necessary for this vulnerable population.
Yazarlar (63)
1
Emel Okulu
2
Ibrahim Murat Hirfanoglu
3
Mehmet Satar
4
Ömer Erdeve
5
Esin Koc
6
Ferda Ozlu
7
Mahmut Gokce
8
Didem Armangil
9
Gaffari Tunç
10
Nihal Demirel
11
Sezin Unal
12
Ramazan Ozdemir
13
Mehmet Fatih Deveci
14
Melek Akar
15
Melike Kefeli Demirel
16
Merih Çetinkaya
17
Halime Sema Can Buker
18
Belma S. Karagol
19
Deniz Yaprak
20
Abdullah Baris Akcan
21
Ayse Anik
22
Fatma Narter
23
Sema Arayici
24
Egemen Yildirim
25
Ilke Mungan Akin
ORCID: 0000-0002-3677-1582
26
Ozlem Sahin
27
Ozgul Emel Bulut Ozdemir
28
Hüsnü Fahri Ovalı
ORCID: 0000-0002-9717-313X
29
Mustafa Ali Akin
30
Yalcin Celik
31
Aysen Orman
32
Sinan Uslu
33
Hilal Ozkan
34
Nilgun Koksal
35
Ayhan Tastekin
36
Mehmet Gunduz
37
Ayse Engin Arisoy
38
Resat Gurpinar
39
Rahmi Örs
40
Huseyin Altunhan
41
Ramazan Kececi
42
Hacer Yapicioglu Yildizdas
43
Demet Terek
44
Mehmet Ates
45
Sebnem Kader
46
Mehmet Mutlu
47
Kiymet Çelik
48
Ebru Yucesoy
49
Mustafa Kurthan Mert
50
Selvi Gulasi
51
Kazim Kucuktasci
52
Didem Arman
53
Berna Hekimoglu
54
Nazli Dilay Gultekin
55
Hasan Tolga Çelik
ORCID: 0000-0002-1725-0722
56
Dilek Kahvecioğlu
57
Can Akyildiz
58
Erdal Taşkin
59
Nukhet Aladag Ciftdemir
60
Saime Sundus Uygun
61
Tugba Barsan Kaya
62
Arzu Akdag
63
Aslan Yilmaz
Kurumlar
Adana Devlet Hastanesi
Adana Turkey
Akdeniz University, Faculty of Medicine
Antalya Turkey
Ankara Üniversitesi
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Cumhuriyet Üniversitesi Tip Fakültesi
Sivas Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Eskisehir State Hospital
Eskisehir Turkey
Etlik Zübeyde Hanim Women's Health Teaching and Research Hospital
Ankara Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Harran University, Faculty of Medicine
Sanliurfa Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Karadeniz Teknik Üniversitesi Tip Fakültesi
Trabzon Turkey
Kocaeli Üniversitesi
İzmit Turkey
Koru Hospital
Ankara Türkiye
Medeniyet University
Istanbul Turkey
Medova Hospital
Konya Turkey
Mersin Üniversitesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Ozel Saglik Hospital
Denizli Turkey
T. C. Sağlık Bakanlığı, Taksim Eğitim ve Araştirma Hastanesi
Istanbul Turkey
Trakya University, Faculty of Medicine
Edirne Turkey
University of Health Sciences
Istanbul Turkey
Van Regional Training and Research Hospital
Van Turkey
Metrikler
4
Atıf
63
Yazar