Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Frontiers in Nutrition · Ocak 2024
YÖKSİS Kayıtları
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Frontiers in Nutrition · 2024 SSCI
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Frontiers in Nutrition · 2024 SCI
DOÇENT MURAT KONAK →
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Frontiers in Nutrition · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Frontiers in Nutrition · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ SAİME SÜNDÜS UYGUN →
Makale Bilgileri
DergiFrontiers in Nutrition
Yayın TarihiOcak 2024
Cilt / Sayfa11
Scopus ID2-s2.0-85206086113
Erişim🔓 Açık Erişim
Özet
Objective: The objective of this study was to evaluate the efficacy and safety of isotonic and hypotonic intravenous fluids in maintenance fluid therapy for term infants. Methods: This was a multi-centre, prospective, observational study conducted in 21 participating centres from December 30, 2020, to June 30, 2023. The study included term newborns requiring parenteral fluid therapy for maintenance (NCT04781361). The fluid treatment was divided into two groups based on the concentration of sodium in the parenteral fluid, designated as hypotonic (NaCl <130 mmol/L) and isotonic (NaCl = 130–154 mmol/L). The primary outcomes were the change in mean plasma sodium (pNa) levels per hour (∆pNa mmol/L/h), the incidence of hyponatremia (pNa <135 mmol/L) and hypernatremia (pNa >145 mmol/L), and the occurrence of clinically significant changes in sodium levels (∆pNa >0.5 mmol/L/h). Results: A total of 420 patients from 21 centers were included. The ∆pNa was negative in the hypotonic fluid group and positive in the isotonic fluid group, with a significant difference between the groups [respectively −0.07 ± 0.03 (95% CI: −0.13 to −0.02); 0.04 ± 0.03 (95%CI: −0.02 to 0.09), p = 0.04]. There was no difference between the groups in terms of the development of hypernatremia or a clinically meaningful pNa increase. The hypotonic fluid group had a higher incidence of hyponatremia and a clinically meaningful sodium decrease compared to the isotonic fluid group [7.9% vs. 1.2% (OR:6.5, p:0.03)] and [12.2% vs.4.2% (OR:2.9, p = 0.03)]. Conclusion: Contrary to current understanding, this large-scale study is the first to demonstrate that the use of hypotonic fluids in maintenance fluid therapy for newborns poses a risk of hyponatremia development, whereas isotonic fluid therapy appears safe.
Yazarlar (31)
1
Hasan Ozkan
2
Nuray Duman
3
Funda Tuzun
4
Fatma Narter
5
Can Akyildiz
6
Emel Altuncu
7
Mehmet Satar
8
Mustafa Ozdemir
9
Abdullah Kurt
10
Ali U. Tugcu
11
Murat Konak
12
Saime Sundus Uygun
13
Seda Yilmaz Semerci
14
Rahime T. Dikmen
15
Bora Baysal
16
Cemile K. Zeybek
17
Yasemin Ezgi Kostekci
18
Suzan Sahin
19
Merve Tutal
20
Ayse Anik
21
Mehmet Buyuktiryaki
22
Belma S. Karagol
23
Gaffari Tunç
24
Derya Colak
25
Hasan Cetin
26
Aysen Orman
27
Ozgur Olukman
28
Mehmet Fatih Deveci
29
Dilek Sarici
30
Salih C. Cakir
31
Pembe Keskinoglu
Anahtar Kelimeler
fluid therapy
hypernatremia
hyponatremia
hypotonic
isotonic
maintenance
newborn
tonicity
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Aydin Adnan Menderes University
Aydin Turkey
Aydın Child and Women Hospital
Aydin Turkey
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Cumhuriyet Üniversitesi Tip Fakültesi
Sivas Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
İstanbul Medipol Üniversitesi
Istanbul Turkey
Izmir Bakircay University
Izmir Turkey
Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
Istanbul Türkiye
Kartal Education and Research Hospital
Istanbul Turkey
Malatya Eğitim ve Araştırma Hastanesi
Malatya Turkey
Mersin Üniversitesi
Mersin Turkey
Samsun Training and Research Hospital
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel University, Faculty of Medicine
Isparta Turkey
University of Health Sciences
Istanbul Turkey
Usak University
Usak Turkey