Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia
Tuberkuloz ve Toraks · Ocak 2017
YÖKSİS Kayıtları
Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia
Tuberkuloz ve Toraks · 2017 Scopus
PROFESÖR RECAİ ERGÜN →
Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia
Tuberkuloz ve Toraks · 2017 IM: Index Medicus
PROFESÖR RECAİ ERGÜN →
Makale Bilgileri
DergiTuberkuloz ve Toraks
Yayın TarihiOcak 2017
Cilt / Sayfa65 · 271-281
Scopus ID2-s2.0-85042521325
Erişim🔓 Açık Erişim
Özet
Introduction: Colistimethate sodium (CMS) is frequently used in the treatment of nosocomial multidrug-resistant gram-negative infections. Nephrotoxicity is the most important side effect. The aim of this study is to evaluate the effect of colistin on nephrotoxicity and to assess prognosis in patients treated with CMS due to hospital-acquired pneumonia (HAP). Materials and Methods: Patients treated with CMS for HAP due to multidrug-resistant Pseudomonas aeruginosa or Acinetobacter baumannii were included in this cohort study. Results: We evaluated 281 patients treated with two different brands of CMS whose administration dose is different: imported (n= 58, low dose/kg) and domestic (n= 223, high dose/kg). Nephrotoxicity developed in 175 patients (62.3%). The median age (73 vs. 66 years, p= 0.004) and mortality rates were higher (66.9% vs. 52.8%, p= 0.022) in patients having nephrotoxicity. The patients receiving high dose/kg had higher nephrotoxicity rate (67.7% vs. 41.4%, p< 0.001). The clinical, bacteriological response and mortality rates of the whole group were 52.0%, 61.0%, 61.6%, respectively. The clinical and bacteriological response rates were similar in the different dose groups. Multivariate analysis showed that nephrotoxicity was associated with domestic brand depending on use of high dose (OR= 3.97), advanced age (β= 0.29, p= 0.008), male gender (OR= 2.60), hypertension (OR= 2.50), red blood cells transfusion (OR= 2.54), absence of acute kidney injury (OR= 10.19), risk stage of RIFLE (OR= 11.9). Conclusion: Nephrotoxicity is associated with the use of high dose colistin, age, gender, hypertension, red blood cells replacement and RIFLE stage. The mortality rate is higher in patients developing nephrotoxicity.
Yazarlar (18)
1
Pervin Korkmaz Ekren
2
Zehra Nur Töreyin
3
Huriye Berk Takir
4
Merih Kalamanoğlu Balci
5
Ümmügülsün Gaygısız
6
Gul Gursel
7
Begüm Ergan
ORCID: 0000-0003-2920-9214
8
Aslihan Yalcin
9
Cüneyt Saltürk
10
Müge Aydoğdu
ORCID: 0000-0001-6146-4173
11
Recai Ergün
12
Pınar Güven
13
Gaye Ulubay
14
Aslihan Gurun Kaya
15
Aygul Celtik
16
Hatice Uluer
17
Feza Bacakoğlu
18
Abdullah Sayiner
Anahtar Kelimeler
Colistimethate sodium
Multidrug resistant
Nosocomial infection
Pneumonia
Toxicity
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Başkent Üniversitesi
Ankara Turkey
Ege Üniversitesi
Izmir Turkey
Gazi Üniversitesi
Ankara Turkey
Istanbul Sureyyapasa Chest Disesases and Chest Surgery Training and Research Hospital
Istanbul Turkey
Marmara Üniversitesi
Istanbul Turkey
T. C. Sağlık Bakanlığı Ankara Diskapi Yildirim Beyazit Eğitim ve Araştirma Hastanesi
Ankara Turkey
Metrikler
5
Atıf
18
Yazar
5
Anahtar Kelime