Scopus
YÖKSİS Eşleşti
Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study
Journal of Critical Care · Ekim 2023
YÖKSİS Kayıtları
Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study
Journal of Critical Care · 2023 SCI-Expanded
PROFESÖR RECAİ ERGÜN →
Makale Bilgileri
DergiJournal of Critical Care
Yayın TarihiEkim 2023
Cilt / Sayfa77
Scopus ID2-s2.0-85159090175
Özet
Background/Objectives: Thiamine plays a pivotal role in energy metabolism. The aim of the study was to determine serial whole blood TPP concentrations in critically ill patients receiving chronic diuretic treatment before ICU admission and to correlate TPP levels with clinically determined serum phosphorus concentrations. Subjects/Methods: This observational study was performed in 15 medical ICUs. Serial whole blood TPP concentrations were measured by HPLC at baseline and at days 2, 5 and 10 after ICU admission. Results: A total of 221 participants were included. Of these, 18% demonstrated low TPP concentrations upon admission to the ICU, while 26% of participants demonstrated low levels at some point during the 10-day study period. Hypophosphatemia was detected in 30% of participants at some point during the 10-day period of observation. TPP levels were significantly and positively correlated with serum phosphorus levels at each time point (P < 0.05 for all). Conclusions: Our results show that 18% of these critically ill patients exhibited low whole blood TPP concentrations on ICU admission and 26% had low levels during the initial 10 ICU days, respectively. The modest correlation between TPP and phosphorus concentrations suggests a possible association due to a refeeding effect in ICU patients requiring chronic diuretic therapy.
Yazarlar (30)
1
Kürşat Gündoğan
ORCID: 0000-0002-8433-3480
2
Gulsah G. Sahin
3
Serap S. Ergul
4
Nurhayat T. Ozer
5
Şahin Temel
ORCID: 0000-0002-2766-4312
6
Türkay Akbaş
ORCID: 0000-0002-2150-6866
7
Talha Ercan
8
Hamit Yildiz
9
Oğuzhan Sıtkı Dizdar
10
Zuhal Simsek
11
Kaniye Aydın
12
Ramazan Ulu
ORCID: 0000-0003-1461-2764
13
Avşar Zerman
ORCID: 0000-0003-0957-0766
14
Hayriye C. Dal
15
Emre Aydın
ORCID: 0000-0001-7657-3065
16
Ezgi Özyılmaz
ORCID: 0000-0002-4535-705X
17
Nazire Ateş
18
Kamil Gonderen
19
Nazif Yalcin
20
Arzu Topeli
ORCID: 0000-0002-5874-9087
21
Gulay Tok
22
Özlem Edipoğlu
23
Begüm Ergan
ORCID: 0000-0003-2920-9214
24
Ferhan Aydemir
ORCID: 0000-0002-6740-1496
25
İsmail Hakkı Akbudak
ORCID: 0000-0002-3716-9243
26
Recai Ergün
27
Recep Civan Yüksel
ORCID: 0000-0003-4496-9473
28
Murat Sungur
ORCID: 0000-0002-0011-3166
29
Daniel P. Griffith
30
Thomas R. Ziegler
Anahtar Kelimeler
Critical illness
Diuretics
Refeeding syndrome
Thiamine
Kurumlar
Canakkale Mehmet Akif Ersoy State Hospital
Canakkale Türkiye
Çukurova Üniversitesi Tip Fakültesi
Adana Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Düzce Üniversitesi
Duzce Turkey
Emory University Hospital
Atlanta United States
Emory University School of Medicine
Atlanta United States
Erciyes Üniversitesi
Kayseri Turkey
Erciyes University, Faculty of Medicine
Kayseri Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Hacettepe Üniversitesi
Ankara Turkey
Kayseri Training and Research Hospital
Kayseri Turkey
Kırşehir Ahi Evran Üniversitesi
Kirsehir Turkey
Pamukkale Üniversitesi Tip Fakültesi
Denizli Turkey
Selçuk Tip Fakültesi
Konya Turkey
T.C. Ministry of Health Kütahya Health Sciences University Evliya Çelebi Education and Research Hospital
Kutahya Turkey
Turkiye Yuksek Ihtisas Hospital
Ankara Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
5
Atıf
30
Yazar
4
Anahtar Kelime