Scopus
YÖKSİS Eşleşti
Can Serum Chitotriosidase Levels, Immune, and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis?
Journal of Occupational and Environmental Medicine · Aralık 2023
YÖKSİS Kayıtları
Can Serum Chitotriosidase Levels, Immune, and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis?
Journal of Occupational and Environmental Medicine · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Can Serum Chitotriosidase Levels, Immune, and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis?
Journal of Occupational and Environmental Medicine · 2023 SCI-Expanded
PROFESÖR RECAİ ERGÜN →
Can Serum Chitotriosidase Levels, Immune, and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis?
Journal of Occupational and Environmental Medicine · 2023 SCI-Expanded
DOÇENT DİLEK ERGÜN →
Makale Bilgileri
DergiJournal of Occupational and Environmental Medicine
Yayın TarihiAralık 2023
Cilt / Sayfa65 · E752-E758
Scopus ID2-s2.0-85178649195
Özet
Objective We aimed to evaluate the enzyme activity of chitotriosidase as a biomarker in early diagnosis silicosis and to investigate immune system response and oxidative stress caused by silica exposure. Materials and Methods Silicosis patients (n = 116), exposed to silica without disease (n = 76), and healthy individuals (n = 55) were included. Serum levels of chitotriosidase, proinflammatory cytokines, oxidant-antioxidant, and immune parameters were measured. Results Serum chitotriosidase enzyme levels in the silicosis group were statistically significantly higher than the exposure and control groups. Inflammatory biomarkers and 8-hydroxy-2-deoxyguanosine levels were found to be statistically significantly higher in the silicosis and exposure group compared with the controls, while superoxide dismutase and glutathione peroxidase were lower. Conclusions Increased serum chitotriosidase level emerged as a biomarker that can not only distinguish silicosis from exposure and healthy controls but also indicate early pulmonary effects of silica.
Yazarlar (6)
1
Recai Ergün
2
Dilek Ergün
3
Esin Özkan
4
Ozlem Kar Kurt
5
Merve Bacanli
6
M. K. Korez
ORCID: 0000-0001-9524-6115
Anahtar Kelimeler
chitotriosidase
immune parameters
occupational exposure
oxidative stress parameters
silicosis
Kurumlar
Rush University Medical Center
Chicago United States
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital
Istanbul Turkey