Scopus
YÖKSİS Eşleşti
Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease
Journal of Pediatric Endocrinology and Metabolism · Ekim 2012
YÖKSİS Kayıtları
Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease
Journal of Pediatric Endocrinology and Metabolism · 2012 SCI-Expanded
PROFESÖR AHMET SERT →
Makale Bilgileri
DergiJournal of Pediatric Endocrinology and Metabolism
Yayın TarihiEkim 2012
Cilt / Sayfa25 · 927-934
Scopus ID2-s2.0-84867830463
Özet
Background/aims: No data are available examining the relationship between carotid intima media thickness (IMT) and left ventricular mass (LVM) in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Therefore, we investigated LVM and carotid IMT in obese adolescents with NAFLD. Methods: Eighty obese adolescents and 37 lean subjects were enrolled in the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for serum transaminases, glucose and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Results: LVM measurements were higher in both NAFLD and non-NAFLD obese patients in comparison with the lean children. The NAFLD group had significantly higher LVM measurements than the non-NAFLD and lean groups. Carotid IMT was higher in both the NAFLD and non-NAFLD obese patients in comparison with the lean group. The NAFLD group had significantly higher carotid IMT measurements than the non-NAFLD and lean groups. LVM was positively correlated with HOMA-IR and serum alanine aminotransferase levels in the NAFLD obese group. Carotid IMT was positively correlated with HOMAIR, serum alanine aminotransferase levels and LVM in the NAFLD obese group. Conclusions: We demonstrated that obese adolescents with NAFLD have increased LVM and carotid IMT and low insulin sensitivity. Obese adolescents with NAFLD and increased carotid IMT may demonstrate a more adverse cardiovascular risk profile and higher LVM. Therefore, assessment of carotid IMT, in addition to echocardiography, may assist in risk stratification in obese adolescents with NAFLD with elevated cardiovascular risk factor levels.
Yazarlar (5)
1
Ahmet Sert
ORCID: 0000-0002-1607-7569
2
Ozgur Pirgon
3
Ebru Aypar
4
Hakan Yilmaz
5
Dursun Odabas
Anahtar Kelimeler
Adolescent
Carotid intima media thickness
Insulin resistance
Left ventricular mass
Non-alcoholic fatty liver disease
Kurumlar
Konya Meram Training and Research Hospital
Konya Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
Metrikler
25
Atıf
5
Yazar
5
Anahtar Kelime