Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Relationship between aspartate aminotransferase to-platelet ratio index and carotid intima-media thickness in obese adolescents with non-alcoholic fatty liver disease
JCRPE Journal of Clinical Research in Pediatric Endocrinology · Eylül 2013
YÖKSİS Kayıtları
Relationship Between Aspartate Aminotransferase to Platelet Ratio Index and Carotid Intima Media Thickness in Obese Adolescents with Non Alcoholic Fatty Liver Disease
Journal of Clinical Research in Pediatric Endocrinology · 2013 SCI-Expanded
PROFESÖR AHMET SERT →
Makale Bilgileri
DergiJCRPE Journal of Clinical Research in Pediatric Endocrinology
Yayın TarihiEylül 2013
Cilt / Sayfa5 · 182-188
Scopus ID2-s2.0-84884230267
Erişim🔓 Açık Erişim
Özet
Objective: There is increasing evidence for an association between nonalcoholic fatty liver disease (NAFLD) and an increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the association between aspartate aminotransferase-to-platelet ratio index (APRI) and carotid intima-media thickness (IMT) in obese adolescents with NAFLD. Methods: Seventy-six obese adolescents and 36 lean subjects were enrolled in this cross-sectional single-centre study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminase levels (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for transaminase, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Results: APRI values were higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher APRI values than the non-NAFLD obese group and the lean group. Carotid IMT was higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher measurements of carotid IMT than the non-NAFLD group and the lean group. APRI was positively correlated with most of the metabolic parameters (total cholesterol, low-density lipoprotein cholesterol, glucose, insulin, HOMA-IR) and with carotid IMT in the NAFLD obese group. Conclusions: This study demonstrated that a significant relationship exists between APRI and carotid IMT in obese adolescents with NAFLD. We suggest that an increased APRI score in obese adolescents with NAFLD can possibly serve to predict a more adverse cardiovascular risk profile. © Journal of Clinical Research in Pediatric Endocrinology.
Yazarlar (5)
1
Ahmet Sert
ORCID: 0000-0002-1607-7569
2
Ozgur Pirgon
3
Ebru Aypar
4
Hakan Yilmaz
5
B. Dundar
Anahtar Kelimeler
Adolescent
Aspartate aminotransferase-to-platelet ratio index
Carotid intima-media thickness
Insulin resistance
Non-alcoholic fatty liver disease
Obesity
Kurumlar
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
Metrikler
21
Atıf
5
Yazar
6
Anahtar Kelime