Scopus
YÖKSİS Eşleşti
Blue rubber bleb nevus syndrome: Successful treatment with sirolimus
Pediatrics · Ocak 2012
YÖKSİS Kayıtları
Blue Rubber Bleb Nevus Syndrome: Successful Treatment With Sirolimus
PEDIATRICS · 2012 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Blue Rubber Bleb Nevus Syndrome Successful Treatment With Sirolimus
PEDIATRICS · 2012 SCI
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiPediatrics
Yayın TarihiOcak 2012
Cilt / Sayfa129
Scopus ID2-s2.0-84859386796
Özet
Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder with characteristic vascular malformations of the skin, gastrointestinal system, and, less often, other organ systems. The characteristic cutaneous lesions consist of deep-blue, soft, rubbery blebs, which are easily compressible. The most serious complication is abundant gastrointestinal bleeding. We describe the case of an 8-year-old girl with diagnosed BRBNS who had multiple venous malformations all over her body, importantly, throughout the gastrointestinal tract, mouth, esophagus, stomach, small bowel, and colon. She presented with recurrent massive gastrointestinal bleeding and soft tissue hematoma despite prednisolone and a-interferon therapy. We started low-dose sirolimus as an antiangiogenic agent. The vascular masses were reduced rapidly and there was no gastrointestinal bleeding and muscular hematoma after sirolimus therapy. There was no drug adverse reaction at 20-month follow-up. To the best of our knowledge, this is the first report related to the use of sirolimus in a patient with BRBNS. Copyright © 2012 by the American Academy of Pediatrics.
Yazarlar (4)
1
H. Yuksekkaya
2
O. Ozbek
3
Melike Emiroglu
ORCID: 0000-0003-1307-0246
4
Hatice Toy
Anahtar Kelimeler
Blue rubber bleb nevus syndrome
Gastrointestinal bleeding
Hemangiomatosis
Sirolimus
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
112
Atıf
4
Yazar
4
Anahtar Kelime