Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Clinical features of candidiasis in patients with inherited interleukin 12 receptor β1 deficiency
Clinical Infectious Diseases · Ocak 2014
YÖKSİS Kayıtları
Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor 1 Deficiency
Clinical Infectious Diseases · 2013 SCI
DOÇENT MELİKE EMİROĞLU →
Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor β1 Deficiency
Clinical Infectious Diseases · 2013 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiClinical Infectious Diseases
Yayın TarihiOcak 2014
Cilt / Sayfa58 · 204-213
Scopus ID2-s2.0-84891754308
Erişim🔓 Açık Erişim
Özet
Background. Interleukin 12Rβ1 (IL-12Rβ1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12Rβ1 deficiency.Results. Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2) with OPC in 1 patient, whereas isolated vulvovaginal candidiasis (VVC; n = 3) was not. Five episodes of proven invasive candidiasis were documented in 4 patients; 1 of these episodes was community acquired in the absence of any other comorbid condition. The first episode of candidiasis occurred earlier in life (median age±standard deviation, 1.5 ± 7.87 years) than infections with environmental mycobacteria (4.29 ± 11.9 years), Mycobacterium tuberculosis (4 ± 3.12 years), or Salmonella species (4.58 ± 4.17 years) or other rare infections (3 ± 11.67 years). Candidiasis was the first documented infection in 19 of the 35 patients, despite the vaccination of 10 of these 19 patients with live bacille Calmette-Guérin.Conclusions. Patients who are deficient in IL-12Rβ1 may have candidiasis, usually mucocutaneous, which is frequently recurrent or persistent. Candidiasis may be the first clinical manifestation in these patients. © The Author 2013.
Yazarlar (42)
1
Monia Ouederni
2
Ozden Sanal
3
Aydan Ikinciogullari
4
Ilhan Tezcan
5
Figen Dogu
6
Ithaisa Sologuren
7
Sigifredo Pedraza-Sánchez
8
Melike Emiroglu
ORCID: 0000-0003-1307-0246
9
Gonul Tanir
10
Chris Nieuwhof
11
Elena Colino
12
Dinakantha Kumararatne
13
Jacov Levy
14
Necil Kütükçüler
15
Caner Aytekin
16
Estefanía Herrera-Ramos
17
Micah Bhatti
18
Neslihan Karaca
19
Mohamed Rhida Barbouche
20
Arnon Broides
21
Ekaterini Goudouris
22
Jose Luis Franco
23
Nima Parvaneh
ORCID: 0000-0002-3397-9716
24
Ismail Reisli
25
Alexis Strickler
26
Anna Shcherbina
27
Ayper Somer
28
Anthony Segal
29
Alfonso Angel-Moreno
30
José Luis Lezana-Fernandez
31
Mohamed Bejaoui
32
Miriam Bobadilla-Del Valle
33
Salem Kachboura
34
Timothy Sentongo
35
Imen Ben-Mustapha
36
Jacinta Bustamante
37
Capucine Picard
38
Anne Puel
39
Stéphanie Boisson-Dupuis
40
Laurent Abel
ORCID: 0000-0001-7016-6493
41
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
42
Carlos Rodriguez-Gallego
Anahtar Kelimeler
Candida
Interleukin-12 receptor β1 chain
Mycobacterium
Primary immunodeficiency
Salmonella
Kurumlar
Addenbrooke's Hospital
Cambridge United Kingdom
Ankara Üniversitesi
Ankara Turkey
Ariana Hospital
Tunis Tunisia
Ben-Gurion University of the Negev
Beer-Sheva Israel
Centre National de Greffe de Moelle Osseuse
Tunis Tunisia
Comer Children's Hospital - Hyde Park
Chicago United States
Complejo Hospitalario Universitario Insular Materno-Infantil
Las Palmas de Gran Canaria Spain
Dr. Sami Ulus Children's Hospital
Ankara Turkey
Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Center
Turkey
Ege University Medical School
Izmir Turkey
Faculté de Médecine de Tunis
Tunis Tunisia
Gran Canaria Dr Negrín University Hospital
Japan
Hacettepe Üniversitesi
Ankara Turkey
Hôpital Necker Enfants Malades
Paris France
Hospital Infantil de México Federico Gómez
Mexico Mexico
Hospital Puerto Montt
Puerto Montt Chile
Institut National de la Santé et de la Recherche Médicale
Switzerland
Institut Pasteur de Tunis
Tunis Tunisia
İstanbul Tıp Fakültesi
Istanbul Turkey
Maastricht Universitair Medisch Centrum+
Maastricht Netherlands
National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ
Mexico
Necmettin Erbakan Üniversitesi
Meram Turkey
Oncology
Moscow Russian Federation
Rockefeller University
New York United States
Tehran University of Medical Sciences
Tehran Iran
The University of Chicago Medicine
Chicago United States
Unit of Biochemistry
Spain
Universidad de Antioquia
Medellin Colombia
Universidad de Las Palmas de Gran Canaria
Las Palmas de Gran Canaria Spain
Universidade Federal do Rio de Janeiro
Rio de Janeiro Brazil
Université Paris Cité
Paris France
University College London
London United Kingdom
Metrikler
103
Atıf
42
Yazar
5
Anahtar Kelime