Scopus
YÖKSİS Eşleşti
Toxic epidermal necrolysis treated with N-acetylcysteine
Pediatrics International · Ekim 2014
YÖKSİS Kayıtları
Toxic epidermal necrolysis treated withN acetyl cystein
PEDIATRICS INTERNATIONAL · 2014 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiPediatrics International
Yayın TarihiEkim 2014
Cilt / Sayfa56 · e52-e54
Scopus ID2-s2.0-84939233006
Özet
Adverse drug reactions are the major cause of morbidity and mortality worldwide. Cutaneous drug reaction is the most common type of adverse reaction. Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous disease, usually attributable to drugs. There is no proven therapy for TEN. The mainstay of therapy is immediate withdrawal of the culprit drug, using disease-modifying agents, and meticulous supportive care. Several disease-modifying agents have been used such as steroid, i.v. human immunoglobulin (IVIg), plasmapheresis. A 10-year-old epileptic girl was admitted with lamotrigine-induced TEN. She was unresponsive to steroid. Her condition deteriorated despite IVIg treatment. She was treated with N-acetylcysteine (NAC). To our knowledge this is the first report of a child with TEN, a potentially lethal disorder, treated with NAC. NAC may be effective for children with TEN.
Yazarlar (2)
1
Haluk Yavuz
2
Melike Emiroglu
ORCID: 0000-0003-1307-0246
Anahtar Kelimeler
cutaneous drug reaction
i.v. human immunoglobulin
lamotrigine
N-acetylcysteine
toxic epidermal necrolysis
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Metrikler
8
Atıf
2
Yazar
5
Anahtar Kelime