Scopus
YÖKSİS Eşleşti
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
Immunological Reviews · Mart 2015
YÖKSİS Kayıtları
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
Immunological Reviews · 2015 SCI
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiImmunological Reviews
Yayın TarihiMart 2015
Cilt / Sayfa264 · 103-120
Scopus ID2-s2.0-84923170439
Özet
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely elusive, as only a small proportion of infected individuals develop clinical disease either during primary infection or during reactivation from latency or secondary infection. Subacute, hematogenous, and extrapulmonary disease tends to be more frequent in infants, children, and teenagers than in adults. Life-threatening primary TB of childhood can result from known acquired or inherited immunodeficiencies, although the vast majority of cases remain unexplained. We review here the conditions conferring a predisposition to childhood clinical diseases caused by mycobacteria, including not only M.tb but also weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria. Infections with weakly virulent mycobacteria are much rarer than TB, but the inherited and acquired immunodeficiencies underlying these infections are much better known. Their study has also provided genetic and immunological insights into childhood TB, as illustrated by the discovery of single-gene inborn errors of IFN-γ immunity underlying severe cases of TB. Novel findings are expected from ongoing and future human genetic studies of childhood TB in countries that combine a high proportion of consanguineous marriages, a high incidence of TB, and an excellent clinical care, such as Iran, Morocco, and Turkey.
Yazarlar (41)
1
Stéphanie Boisson-Dupuis
2
Jacinta Bustamante
3
Jamila El Baghdadi
4
Yıldız Camcıoglu
5
Nima Parvaneh
ORCID: 0000-0002-3397-9716
6
Safa El Azbaoui
7
Aomar Agader
8
Amal Hassani
9
Naima El Hafidi
10
Nidal Alaoui Mrani
11
Zineb Jouhadi
12
Fatima Ailal
13
Jilali Najib
14
Ismail Reisli
15
Adil Zamani
16
Şebnem Yosunkaya
17
Saniye Gulle-Girit
18
A. Yildiran
19
Funda E. Cipe
20
Selda Hancerli Torun
21
Ayse Metin
22
Başak Yıldız Atikan
ORCID: 0000-0002-9617-3963
23
Nevin Hatipoglu
24
Cigdem Aydogmus
25
Sara S. Kilic
26
Figen Dogu
27
Neslihan Karaca
28
Guside Aksu
29
Necil Kütükçüler
30
Melike Emiroglu
ORCID: 0000-0003-1307-0246
31
Ayper Somer
32
Gonul Tanir
33
Caner Aytekin
34
Parisa Adimi
35
Seyed Alireza Mahdaviani
36
Setareh Mamishi
37
Ahmed A. Bousfiha
38
Ozden Sanal
39
Davood Mansouri
40
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
41
Laurent Abel
ORCID: 0000-0001-7016-6493
Anahtar Kelimeler
Children
Human genetics
IFN-γ
Mendelian susceptibility to mycobacterial diseases (MSMD)
Primary immunodeficiency
Kurumlar
Ankara Oncology Hospital
Ankara Turkey
Ankara Üniversitesi
Ankara Turkey
Bak?rkoy Dr. Sadi Konuk Egitim ve Arast?rma Hastanesi
Istanbul Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Centre Hospitalier Universitaire Ibn Rochd
Casablanca Morocco
Children's Medical Center (TUMS)
Tehran Iran
CHU Averroes
Casablanca Morocco
Ege University Medical School
Izmir Turkey
Faculté de Médecine et de Pharmacie de Rabat
Rabat Morocco
Faculty of Science, Ibn Tofail University
Kenitra Morocco
Hacettepe Üniversitesi
Ankara Turkey
Hassan II University of Casablanca
Casablanca Morocco
Hôpital Necker Enfants Malades
Paris France
Howard Hughes Medical Institute
Chevy Chase United States
İstanbul Tıp Fakültesi
Istanbul Turkey
Kanuni Sultan Suleyman Training and Research Hospital
Istanbul Turkey
Kartal Dr. Lütfi Kırdar City Hospital
Istanbul Türkiye
l'Institut des Maladies Génétiques Imagine
Paris France
Military Hospital Mohammed V
Agdal Rabat Morocco
National Research Institute of Tuberculosis and Lung Disease Tehran
Tehran Iran
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Research Center for Immunodeficiencies
Tehran Iran
Rockefeller University
New York United States
Selçuk Tip Fakültesi
Konya Turkey
Tehran University of Medical Sciences
Tehran Iran
Training and Research Hospital
Ankara Turkey
Université Paris Cité
Paris France
Metrikler
174
Atıf
41
Yazar
5
Anahtar Kelime