Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · Ekim 2020
YÖKSİS Kayıtları
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
PROFESÖR FİKRET KANAT →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiScience
Yayın TarihiEkim 2020
Cilt / Sayfa370
Scopus ID2-s2.0-85094096675
Erişim🔓 Açık Erişim
Özet
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Yazarlar (100)
1
Paul Bastard
2
Lindsey B. Rosen
3
Qian Zhang
4
Eleftherios Michailidis
5
H. Heinrich Hoffmann
6
Yu Zhang
7
Karim Dorgham
8
Quentin Philippot
9
Jérémie Rosain
10
Vivien Béziat
11
Jeremy Manry
12
Elana Shaw
13
Liis Haljasmägi
14
Pärt Peterson
15
Lazaro Lorenzo
16
Lucy Bizien
17
Sophie Trouillet-Assant
18
Kerry Dobbs
ORCID: 0000-0002-3432-3137
19
Adriana Almeida de Jesus
20
Alexandre Belot
ORCID: 0000-0003-4902-5332
21
Anne Kallaste
22
Emilie Catherinot
23
Yacine Tandjaoui-Lambiotte
24
Jérémie Le Pen
25
Gaspard Kerner
26
Benedetta Bigio
27
Yoann Seeleuthner
ORCID: 0000-0002-1878-8567
28
Rui Yang
29
Alexandre Bolze
ORCID: 0000-0001-7399-2766
30
András N. Spaan
31
Ottavia M. Delmonte
32
Michael S. Abers
33
Alessandro Aiuti
34
Giorgio Casari
35
Vito Lampasona
36
Lorenzo Piemonti
37
Fabio Ciceri
38
Kaya Bilguvar
39
Richard P. Lifton
40
Marc Vasse
41
David M. Smadja
42
Mélanie Migaud
43
Jérome Hadjadj
44
Benjamin Terrier
45
Darragh Duffy
46
Lluis Quintana-Murci
47
Diederik van de Beek
48
Lucie Roussel
49
Donald C. Vinh
50
Stuart G. Tangye
51
Filomeen Haerynck
ORCID: 0000-0001-9161-7361
52
David Dalmau
53
Javier Martinez-Picado
54
Petter Brodin
55
Michel C. Nussenzweig
56
Stéphanie Boisson-Dupuis
57
Carlos Rodriguez-Gallego
58
Guillaume Vogt
59
Trine H. Mogensen
60
Andrew J. Oler
61
Jingwen Gu
62
Peter D. Burbelo
63
Jeffrey I. Cohen
64
Andrea Biondi
65
Laura Rachele Bettini
66
Mariella DÁngio
67
Paolo Bonfanti
68
Patrick Rossignol
69
Julien Mayaux
70
Frédéric Rieux-Laucat
ORCID: 0000-0001-7858-7866
71
Eystein Husebye
72
Francesca Fusco
73
Mathilde Valeria Ursini
74
Luisa Imberti
75
Alessandra Sottini
76
Simone Paghera
77
Eugenia Quiros-Roldan
78
Camillo Rossi
79
Riccardo Castagnoli
80
Daniela Montagna
81
Amelia Licari
82
Gian Luigi Marseglia
83
Xavier Duval
84
Jade Ghosn
85
John S. Tsang
86
Raphaela Goldbach-Mansky
87
Kai Kisand
88
Michail S. Lionakis
89
Anne Puel
90
Shen Ying Zhang
ORCID: 0000-0002-9449-3672
91
Steven M. Holland
92
Guy Gorochov
93
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
94
Charles M. Rice
95
Aurélie Cobat
ORCID: 0000-0001-7209-6257
96
Luigi Notarangelo
ORCID: 0000-0002-8335-0262
97
Laurent Abel
ORCID: 0000-0001-7016-6493
98
Helen C. Su
99
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
100
Andrés Augusto Arias
Kurumlar
Aarhus Universitet
Aarhus Denmark
Aarhus Universitetshospital
Aarhus Denmark
AP-HP Assistance Publique - Hopitaux de Paris
Paris France
Centre Hospitalier Lyon-Sud
Lyon France
Centre Universitaire de Santé McGill
Montreal Canada
CHU de Lyon
Lyon France
CNRS Centre National de la Recherche Scientifique
Paris France
Collège de France
Paris France
École Normale Supérieure de Lyon
Lyon France
Foch Hospital
Suresne France
Fondazione IRCCS Policlinico San Matteo
Pavia Italy
Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol
Badalona Spain
Garvan Institute of Medical Research
Sydney Australia
General Universitario
Valencia Spain
Haukeland Universitetssjukehus
Bergen Norway
Helix
San Mateo United States
Hopital Avicenne
Bobigny France
Hôpital Bichat-Claude-Bernard AP-HP
Paris France
Hopital Foch
Suresnes France
Hôpital Necker Enfants Malades
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Universitari de Bellvitge
Barcelona Spain
Howard Hughes Medical Institute
Chevy Chase United States
Innovations Thérapeutiques en Hémostase
Paris France
Inserm
Paris France
Institució Catalana de Recerca i Estudis Avançats
Barcelona Spain
Institute of Genetics and Biophysics Adriano Buzzati Traverso
Naples Italy
Institut Pasteur, Paris
Paris France
IRCCS Ospedale San Raffaele
Milan Italy
Karolinska Institutet
Stockholm Sweden
Karolinska Universitetssjukhuset
Stockholm Sweden
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
National Institute of Dental and Craniofacial Research (NIDCR)
Bethesda United States
National Institutes of Health (NIH)
Bethesda United States
National Referee Centre for Rheumatic
Lyon France
Rockefeller University
New York United States
Sorbonne Université
Paris France
Spedali Civili Di Brescia
Brescia Italy
Tartu Ülikool
Tartu Estonia
Tartu Ülikooli Kliinikum
Tartu Estonia
Universidad de Antioquia
Medellin Colombia
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Brescia
Brescia Italy
Università degli Studi di Milano-Bicocca
Milan Italy
Università degli Studi di Pavia
Pavia Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Universitat de Vic - Universitat Central de Catalunya (UVic-UCC)
Vic Spain
Università Vita-Salute San Raffaele
Milan Italy
Université de Lorraine
Nancy France
Universiteit van Amsterdam
Amsterdam Netherlands
Université Paris Cité
Paris France
Universitetet i Bergen
Bergen Norway
University Medical Center Utrecht
Utrecht Netherlands
UNSW Medicine
Kensington Australia
Yale School of Medicine
New Haven United States
Metrikler
1963
Atıf
100
Yazar