Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science · Ekim 2020
YÖKSİS Kayıtları
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
American Association for the Advancement of Science (AAAS) · 2020 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
DOÇENT GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
American Association for the Advancement of Science (AAAS) · 2020 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiScience
Yayın TarihiEkim 2020
Cilt / Sayfa370
Scopus ID2-s2.0-85094120212
Erişim🔓 Açık Erişim
Özet
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
Yazarlar (67)
1
Qian Zhang
2
Zhiyong Liu
ORCID: 0000-0001-6473-348X
3
Marcela Moncada-Velez
4
Jie Chen
5
Masato Ogishi
6
Benedetta Bigio
7
Rui Yang
8
Andrés Augusto Arias
9
Qinhua Zhou
10
Ji Eun Han
11
Aileen Camille Ugurbil
12
Peng Zhang
13
Franck Rapaport
14
Juan Li
15
András N. Spaan
16
Bertrand Boisson
17
Stéphanie Boisson-Dupuis
18
Jacinta Bustamante
19
Anne Puel
20
Michael J. Ciancanelli
21
Shen Ying Zhang
ORCID: 0000-0002-9449-3672
22
Vivien Béziat
23
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
24
Laurent Abel
ORCID: 0000-0001-7016-6493
25
Aurélie Cobat
ORCID: 0000-0001-7209-6257
26
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
27
Paul Bastard
28
Cecilia Korol
29
Jérémie Rosain
30
Quentin Philippot
31
Marwa Chbihi
32
Lazaro Lorenzo
33
Lucy Bizien
34
Anna Lena Neehus
35
Gaspard Kerner
36
Yoann Seeleuthner
ORCID: 0000-0002-1878-8567
37
Jeremy Manry
38
Tom Le Voyer
ORCID: 0000-0002-7253-3135
39
Jérémie Le Pen
40
William M. Schneider
41
Brandon S. Razooky
42
H. Heinrich Hoffmann
43
Eleftherios Michailidis
44
Charles M. Rice
45
Ira K.D. Sabli
46
Stephanie Hodeib
ORCID: 0000-0002-5978-6189
47
Vanessa Sancho-Shimizu
ORCID: 0000-0002-3519-0727
48
Kaya Bilguvar
49
Junqiang Ye
50
Tom Maniatis
51
Alexandre Bolze
ORCID: 0000-0001-7399-2766
52
Yu Zhang
53
Luigi Notarangelo
ORCID: 0000-0002-8335-0262
54
Helen C. Su
55
Fanny Onodi
56
Sarantis Korniotis
57
Léa Karpf
58
Vassili Soumelis
59
Lucie Bonnet-Madin
60
Ali Amara
61
Karim Dorgham
62
Guy Gorochov
63
Nikaïa Smith
64
Darragh Duffy
65
Leen Moens
66
Isabelle Meyts
67
Philip Meade
Kurumlar
Columbia University
New York United States
Departement Microbiologie, Immunologie en Transplantatie
Leuven Belgium
Helix
San Mateo United States
Hôpital Necker Enfants Malades
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Howard Hughes Medical Institute
Chevy Chase United States
Icahn School of Medicine at Mount Sinai
New York United States
Imperial College London
London United Kingdom
Institut de Recherche Saint-Louis
Paris France
Institut Pasteur, Paris
Paris France
KU Leuven– University Hospital Leuven
Leuven Belgium
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
Rockefeller University
New York United States
Universidad de Antioquia
Medellin Colombia
Université Paris Cité
Paris France
Yale School of Medicine
New Haven United States
Metrikler
1617
Atıf
67
Yazar