Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group
European Journal of Pediatrics · Mayıs 2022
YÖKSİS Kayıtları
COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group
European Journal of Pediatrics · 2022 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group
European Journal of Pediatrics · 2022 SCI-Expanded
PROFESÖR AHMET SERT →
COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group.
European Journal of Pediatrics · 2022 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group
EUROPEAN JOURNAL OF PEDIATRICS · 2022 SCI
DOÇENT GÜLSÜM ALKAN →
Makale Bilgileri
DergiEuropean Journal of Pediatrics
Yayın TarihiMayıs 2022
Cilt / Sayfa181 · 2031-2043
Scopus ID2-s2.0-85124325518
Erişim🔓 Açık Erişim
Özet
Multisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case series designed for patients aged 1 month to 18 years in 28 hospitals between November 1, 2020, and June 9, 2021. Patient demographics, complaints, laboratory results, echocardiographic results, system involvement, and outcomes were recorded. A total of 614 patients were enrolled; the median age was 7.4 years (interquartile range (IQR) 3.9–12 years). A total of 277 (45.1%) patients with MIS-C had manifestations that overlapped with KD, including 92 (33.3%) patients with complete KD and 185 (66.7%) with incomplete KD. Lymphocyte and platelet counts were significantly lower in patients with MISC, overlapped with KD (lymphocyte count 1080 vs. 1280 cells × μL, p = 0.028; platelet count 166 vs. 216 cells × 103/μL, p < 0.001). The median serum procalcitonin levels were statistically higher in patients overlapped with KD (3.18 vs. 1.68 µg/L, p = 0.001). Coronary artery dilatation was statistically significant in patients with overlap with KD (13.4% vs. 6.8%, p = 0.007), while myocarditis was significantly more common in patients without overlap with KD features (2.6% vs 7.4%, p = 0.009). The association between clinical and laboratory findings and overlap with KD was investigated. Age > 12 years reduced the risk of overlap with KD by 66% (p < 0.001, 95% CI 0.217–0.550), lethargy increased the risk of overlap with KD by 2.6-fold (p = 0.011, 95% CI 1.244–5.439), and each unit more albumin (g/dl) reduced the risk of overlap with KD by 60% (p < 0.001, 95% CI 0.298–0.559). Conclusion: Almost half of the patients with MISC had clinical features that overlapped with KD; in particular, incomplete KD was present. The median age was lower in patients with KD-like features. Lymphocyte and platelet counts were lower, and ferritin and procalcitonin levels were significantly higher in patients with overlap with KD.What is Known:• In some cases of MIS-C, the clinical symptoms overlap with Kawasaki disease.• Compared to Kawasaki disease, lymphopenia was an independent predictor of MIS-C.What is New:• Half of the patients had clinical features that overlapped with Kawasaki disease.• In patients whose clinical features overlapped with KD, procalcitonin levels were almost 15 times higher than normal.• Lethargy increased the risk of overlap with KD by 2.6-fold in MIS-C patients.• Transient bradycardia was noted in approximately 10% of our patients after initiation of treatment.
Yazarlar (63)
1
Dilek Yilmaz Ciftdogan
2
Yildiz Ekemen Keles
3
Benhur Şirvan Çetin
ORCID: 0000-0002-8470-4907
4
Nazan Dalgic Karabulut
5
Melike Emiroglu
ORCID: 0000-0003-1307-0246
6
Zafer Bagcı
7
Ayse Buyukcam
8
Emine Hafize Erdeniz
9
Gul Arga
10
Edanur Yesil
11
Ozlem Cakici
12
Adem Karbuz
13
Zümrüt Şahbudak Bal
14
Soner Sertan Kara
15
Arife Ozer
16
Ozge Metin Akcan
17
Sefika Elmas Bozdemir
ORCID: 0000-0003-1058-0320
18
Ayse Berna Anil
19
Hatice Uygun
20
Ömer Kılıç
21
Selda Hancerli Torun
22
Zuhal Umit
23
Murat Sutcu
24
Berfin Ozgokce Ozmen
25
Hatice Karaoglu Asrak
26
Gulsum Alkan
ORCID: 0000-0003-3384-769X
27
Ahu Kara Aksay
28
Cuneyt Ugur
29
Ahmet Ziya Birbilen
ORCID: 0000-0001-7131-3993
30
Burcu Bursal Duramaz
31
Esra Akyuz Ozkan
32
Ozgur Burakay
33
Sema Yildirim Arslan
34
Eda Karadag Oncel
35
Serkan Fazli Celik
36
Ahmet Osman Kilic
37
Seval Ozen
38
Remzi Sarikaya
39
Demet Demirkol
40
Gazi Arslan
41
Ozden Turel
42
Ahmet Sert
ORCID: 0000-0002-1607-7569
43
Ergul Sari
44
Zerrin Orbak
45
Irfan Oguz Sahin
46
Celal Varan
47
Hacer Akturk
48
Sadiye Kubra Tuter Oz
ORCID: 0000-0002-2473-5672
49
Fatih Durak
50
Mehmet B. Oflaz
51
Emine Manolya Kara
52
Derya Karpuz
53
Mey Talip Petmezci
54
Nevin Hatipoglu
55
Selim Oncel
56
Mehmet Turgut
57
Ferhan Elmali
58
Ayper Somer
59
Necdet Kuyucu
60
Ener Cagri Dinleyici
61
Zafer Kurugöl
62
Ergin Ciftci
63
Ates Kara
Anahtar Kelimeler
Children
COVID-19
Kawasaki disease
MIS-C
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Ankara Üniversitesi
Ankara Turkey
Atatürk Üniversitesi
Erzurum Turkey
Aydin Adnan Menderes University
Aydin Turkey
Bakirkoy Sadi Konuk Training and Research Hospital
Istanbul Türkiye
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Bursa Dortcelik Children's Hospital
Bursa Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Erciyes Üniversitesi
Kayseri Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Gaziantep Children's Hospital
Gaziantep Turkey
Hacettepe Üniversitesi
Ankara Turkey
Istanbul Üniversitesi
Istanbul Turkey
İstinye Üniversitesi
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kocaeli Üniversitesi
İzmit Turkey
Koç Üniversitesi
Istanbul Turkey
Manisa City Hospital
Manisa Turkey
Mersin City Hospital
Mersin Turkey
Mersin Üniversitesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Prof. Dr. Cemil Tascioglu City Hospital
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Van Training and Research Hospital
Van Turkey
Metrikler
31
Atıf
63
Yazar
4
Anahtar Kelime