Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis
Journal of Experimental Medicine · Ocak 2023
YÖKSİS Kayıtları
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.
The Journal of Experimental Medicine · 2023 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.
The Journal of Experimental Medicine · 2023 SCI-Expanded
DOÇENT MELİKE EMİROĞLU →
Makale Bilgileri
DergiJournal of Experimental Medicine
Yayın TarihiOcak 2023
Cilt / Sayfa220
Scopus ID2-s2.0-85146519678
Erişim🔓 Açık Erişim
Özet
Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia with a concomitant expansion of CD4−CD8− double-negative (DN) αβ and Vδ2− γδ T lymphocytes, both displaying a unique CD38+CD45RA+T-bet+EOMES− phenotype. Itk-deficient mice recapitulated an expansion of the γδ TandDNαβ T lymphocyte populations in the thymus and spleen, respectively. Moreover, the patients’ T lymphocytes secrete small amounts of IFN-γ in response to TCR crosslinking, mitogens, or forced synapse formation with autologous B lymphocytes. Finally, the patients’ total lymphocytes secrete small amounts of IFN-γ, and CD4+, CD8+,DNαβ T, Vδ2+ γδ T, and MAIT cells display impaired IFN-γ production in response to BCG. Inherited ITK deficiency undermines the development and function of various IFN-γ–producing T cell subsets, thereby underlying TB.
Yazarlar (44)
1
Masato Ogishi
2
Rui Yang
3
Rémy Rodriguez
4
Dominic P. Golec
5
Emmanuel Martin
6
Quentin Philippot
7
Jonathan Bohlen
ORCID: 0000-0003-0458-9484
8
Simon J. Pelham
9
Andrés Augusto Arias
10
Taushif Khan
11
Manar Ata
12
Fatima Al Ali
13
Flore Rozenberg
14
Xiao Fei Kong
15
Maya Chrabieh
16
Candice Laine
17
Weite Lei
18
Ji Eun Han
19
Yoann Seeleuthner
ORCID: 0000-0002-1878-8567
20
Zenia Kaul
21
Emmanuelle Jouanguy
ORCID: 0000-0002-7358-9157
22
Vivien Béziat
23
Leila Youssefian
24
Hassan Vahidnezhad
25
V. Koneti Rao
26
Bénédicte Neven
27
Claire Fieschi
28
Davood Mansouri
29
Mohammad Shahrooei
30
S. Pekcan
31
Gulsum Alkan
ORCID: 0000-0003-3384-769X
32
Melike Emiroglu
ORCID: 0000-0003-1307-0246
33
Hüseyin Tokgöz
34
Jouni Uitto
35
Fabian Hauck
36
Jacinta Bustamante
37
Laurent Abel
ORCID: 0000-0001-7016-6493
38
Sevgi Keles
39
Nima Parvaneh
ORCID: 0000-0002-3397-9716
40
Nico Marr
41
Pamela L. Schwartzberg
42
Sylvain Latour
43
Jean Laurent Casanova
ORCID: 0000-0002-7782-4169
44
Stéphanie Boisson-Dupuis
Kurumlar
Departement Microbiologie, Immunologie en Transplantatie
Leuven Belgium
Hamad Bin Khalifa University, College of Health and Life Sciences
Doha Qatar
Hopital Cochin AP-HP
Paris France
Hôpital Necker Enfants Malades
Paris France
Hôpital Saint-Louis
Paris France
Howard Hughes Medical Institute
Chevy Chase United States
Inserm
Paris France
Institut de Recherche Saint-Louis
Paris France
Klinikum der Universität München
Munich Germany
l'Institut des Maladies Génétiques Imagine
Paris France
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
Necmettin Erbakan Üniversitesi
Meram Turkey
Research Center for Immunodeficiencies
Tehran Iran
Rockefeller University
New York United States
SBUMS Clinical Tuberculosis and Epidemiology Research Center
Tehran Iran
Selçuk Tip Fakültesi
Konya Turkey
Sidney Kimmel Medical College
Philadelphia United States
Sidra Medicine
Doha Qatar
Tehran University of Medical Sciences
Tehran Iran
Universidad de Antioquia
Medellin Colombia
Université Paris Cité
Paris France
Metrikler
15
Atıf
44
Yazar