Scopus
YÖKSİS Eşleşti
Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)
European Journal of Pediatrics · Aralık 2023
YÖKSİS Kayıtları
Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)
Springer Science and Business Media LLC · 2023 SCI-Expanded
PROFESÖR RESUL YILMAZ →
Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)
European Journal of Pediatrics · 2023 SCI-Expanded
PROFESÖR AHMET SERT →
Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)
European Journal of Pediatrics · 2023 SCI-Expanded
DOÇENT GÜLSÜM ALKAN →
Makale Bilgileri
DergiEuropean Journal of Pediatrics
Yayın TarihiAralık 2023
Cilt / Sayfa182 · 5531-5542
Scopus ID2-s2.0-85173919954
Özet
Purpose: Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the third period of the Turk-MISC study group, to compare the clinical and laboratory characteristics and outcomes of MISC patients who did and did not require admission to an intensive care unit (ICU). Methods: This retrospective multicenter observational study was carried out between June 11, 2021, and January 01, 2022. The demographics, complaints, laboratory results, system involvements, and outcomes of the patients were documented. Results: A total of 601 patients were enrolled; 157 patients (26.1%) required hospitalization in the intensive care unit (ICU). Median age was 8 years (interquartile range (IQR) 4.5–11.3 years. The proportion of Kawasaki disease-like features in the ICU group was significantly higher than in the non-ICU group (56.1% vs. 43.2% p = 0.006). The ICU group had considerably lower counts of both lymphocytes and platelets (lymphocyte count 900 vs. 1280 cells × μL, platelet count 153 vs. 212 cells × 103/ μL, all for p< 0.001). C-reactive protein, procalcitonin, and ferritin levels were significantly higher in the ICU group (CRP 164 vs. 129 mg/L, procalcitonin 9.2 vs. 2.2 μg/L, ferritin 644 vs. 334 μg/L, all for p< 0.001). Being between ages 5–12 and older than 12 increased the likelihood of hospitalization in the ICU by four [95% confidence intervals (CI)1.971–8.627] and six times (95% CI 2.575–14.654), respectively, compared to being between the ages 0–5. A one-unit increase in log d-dimer (µg/L) and log troponin (ng/L) was also demonstrated to increase the need for intensive care by 1.8 (95% CI 1.079–3.233) and 1.4 times (95% CI 1.133–1.789), respectively. Conclusion: By comparing this study to our other studies, we found that the median age of MISC patients has been rising. Patients requiring an ICU stay had considerably higher levels of procalcitonin, CRP, and ferritin but significantly lower levels of lymphocyte and thrombocyte. In particular, high levels of procalcitonin in the serum might serve as a valuable laboratory marker for anticipating the need for intensive care. What is Known: • Lymphopenia and thrombocytopenia were an independent predictor factors in patients with MISC who needed to stay in intensive care unit. • The possibility of the need to stay in the intensive care unit in patients with MISC who had Kawasaki disease-like findings was controversial compared with those who did not. What is New: • A one-unit increase log D dimer and log troponin was demonstrated to require for intensive care unit by 1.8 and 1.4 times, respectively. • Serum procalcitonin levels had the best performance to predict stay in the intensive care unit stay.
Yazarlar (92)
1
Dilek Yilmaz
2
Yildiz Ekemen Keles
3
Melike Emiroglu
ORCID: 0000-0003-1307-0246
4
Burcu Bursal Duramaz
5
Cuneyt Ugur
6
Bilge Aldemir Kocabas
7
Talyan Celik
8
Halil Ozdemir
9
Semra Bayturan
10
Ozden Turel
11
Emine Hafize Erdeniz
12
Ozlem Cakici
13
Esra Cakmak Taskin
14
İrem Ceren Erbas
15
Mustafa Genceli
16
Emine Ergul Sari
17
Canan Caymaz
18
Mahmut Can Kizil
19
Murat Sutcu
20
Asuman Demirbuga
21
Gulsum Alkan
ORCID: 0000-0003-3384-769X
22
Zafer Bagcı
23
Gulperi Timurtas Dayar
24
Esra Akyuz Ozkan
25
Ayse Tekin Yilmaz
26
Mehtap Akca
27
Edanur Yesil
28
Soner Sertan Kara
29
Hacer Akturk
30
Belma Yasar
31
Zuhal Umit
32
Hatice Uygun
33
Nurettin Erdem
34
Ayse Buyukcam
35
Eda Karadag Oncel
36
Sadiye Kubra Tuter Oz
ORCID: 0000-0002-2473-5672
37
Hafize Selma Cetin
38
Ayse Berna Anil
39
Resul Yilmaz
40
Neslihan Zengin
41
Selcuk Uzuner
42
Hatice Albayrak
43
Ozgur Borakay
44
Sevgi Topal
45
Gazi Arslan
46
Abdullah Yazar
47
Arife Ozer
48
Tanil Kendirli
49
Emine Manolya Kara
50
Demet Demirkol
51
Fatih Battal
52
Muhammet Kosker
53
Ozge Metin Akcan
54
Hasan Serdar Kihtir
55
Doruk Gul
56
Kazim Zararci
57
Mehmet Alakaya
58
Nilgun Kula
59
Elif Celik
60
Ercument Petmezci
61
Gultac Evren
62
Ahu Kara Aksay
63
Capan Konca
64
Ahmet Sert
ORCID: 0000-0002-1607-7569
65
Derya Arslan
66
Helen Bornaun
67
Onur Tekeli
68
Alkan Bal
69
Irfan Oguz Sahin
70
Selcan Demir
71
Fatih Sap
72
Mehmet Bedir Akyol
73
Ibrahim Cansaran Tanidir
74
Yasemin Nuran Donmez
75
Tayfun Ucar
76
Senay Coban
77
Gul Arga
78
Selda Hancerli Torun
79
Derya Karpuz
80
Serkan Fazli Celik
81
Celal Varan
82
Ferhan Elmali
83
Selim Oncel
84
Nursen Belet
85
Nevin Hatipoglu
86
Nazan Dalgic Karabulut
87
Mehmet Turgut
88
Ayper Somer
89
Necdet Kuyucu
90
Ener Cagri Dinleyici
91
Ergin Ciftci
92
Ates Kara
Anahtar Kelimeler
Children
Intensive care unit
Kawasaki disease
MISC
Kurumlar
Adiyaman Training and Research Hospital
Adiyaman Turkey
Adiyaman Üniversitesi
Adiyaman Turkey
Ankara Üniversitesi
Ankara Turkey
Antalya Training and Research Hospital
Antalya Turkey
Aydin Adnan Menderes University
Aydin Turkey
Bak?rkoy Dr. Sadi Konuk Egitim ve Arast?rma Hastanesi
Istanbul Turkey
Başakşehir Çam ve Sakura City Hospital
Istanbul Turkey
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Çanakkale On Sekiz Mart University
Canakkale Turkey
Celal Bayar Üniversitesi Hastanesi
Izmir Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Erzurum Regional Training and Research Hospital
Erzurum Turkey
Eskisehir City Hospital
Eskisehir Turkey
Eskişehir Osmangazi Üniversitesi
Eskisehir Turkey
Gülhane Eğitim ve Araştırma Hastanesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Health Sciences University Şişli Hamidiye Etfal Training and Research Hospital
Istanbul Turkey
Health Sciences University Van Training and Research Hospital Infectious Diseases Clinic
Van Turkey
Istanbul Üniversitesi
Istanbul Turkey
İstinye Üniversitesi
Istanbul Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kanuni Sultan Suleyman Training and Research Hospital
Istanbul Turkey
Kocaeli Üniversitesi
İzmit Turkey
Koç Üniversitesi
Istanbul Turkey
Manisa City Hospital
Manisa Turkey
Mersin City Hospital
Mersin Turkey
Mersin Üniversitesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
6
Atıf
92
Yazar
4
Anahtar Kelime