Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Bratislava Medical Journal · Ocak 2019
YÖKSİS Kayıtları
The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Bratislava Medical Journal · 2019 SCI-Expanded
PROFESÖR BAHAR ÖÇ →
The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Bratislava Medical Journal · 2019 SCI-Expanded
PROFESÖR HÜLAGU BARIŞKANER →
The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Bratislava Medical Journal · 2019 SCI-Expanded
PROFESÖR MEHMET ALKILIÇ HORASANI ÖÇ →
The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Bratislava Medical Journal · 2019 SCI-Expanded
PROFESÖR OĞUZHAN ARUN →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2019
Cilt / Sayfa120 · 380-385
Scopus ID2-s2.0-85066462300
Erişim🔓 Açık Erişim
Özet
OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10-9, 0-6 M) dexmedetomidine were recorded at 37 °C and at 28 °C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37°C dexmedetomidine resulted in similar significant concentration-dependent contractions in both E+ and E- SV strips (p < 0.05). At 37 °C dexmedetomidine resulted in significant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E- compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E- at 37 °C and also E- 28 °C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV grafts.
Yazarlar (6)
1
Bahar Oc
ORCID: 0000-0002-2253-5191
2
Oguzhan Arun
ORCID: 0000-0001-6101-1481
3
Sengal Taylan
4
Mehmet Oc
ORCID: 0000-0002-7832-3067
5
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
6
Ates Duman
Anahtar Kelimeler
Dexmedetomidine
Hypothermia
Internal mammary artery
In vitro
Normothermia
Saphenous vein
Kurumlar
Hakkari Üniversitesi
Hakkari Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
6
Yazar
6
Anahtar Kelime