Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
Fabad Journal of Pharmaceutical Sciences · Ağustos 2023
YÖKSİS Kayıtları
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
FABAD Farmasotik Bilimler Ankara Dernegi · 2023 SCOPUS
PROFESÖR SALİH MAÇİN →
Makale Bilgileri
DergiFabad Journal of Pharmaceutical Sciences
Yayın TarihiAğustos 2023
Cilt / Sayfa48 · 295-302
Scopus ID2-s2.0-85169542136
Erişim🔓 Açık Erişim
Özet
Cystic Echinococcosis (CE) is a type of zoonotic infection that can be caused by a specific form of a parasite called Echinococcus granulosus sensu lato. Mainly, imaging techniques are utilized to diagnose CE. Serological tests are only used when imaging findings are atypical. Additionally, laboratory assays including, direct microscopy and PCR are used to confirm of diagnosis after treatment though obtained negative results with these tests cannot be ruled out the diagnosis. Specific miRNAs produced by the parasite could be used as markers to diagnose and monitor CE. This research investigates the diagnostic potential of parasite-derived miRNAs compared to the presence of protoscolex in animal-derived hydatid cyst samples. Accordingly, egr-let-7-5p, egr-miR71-5p, and egr-miR-9-5p were positive in 26, 25, and 11 out of 30 samples (86.6%, 83.3%, and (36.6%), respectively. There was no relationship between protoscolex presence and detection of either egr-let-7-5p or egr-miR-9-5p (p>0.05). On the other hand, egr-miR71-5p positivity was found to be statistically significant compared with protoscolex presence (p=0.04). As a result, egr-miR-71 is a promising potential target for the diagnosis of CE. Additional research is necessary to assess the diagnostic value of miRNAs in CE using a larger group of samples.
Yazarlar (3)
1
Serra Örsten
ORCID: 0000-0002-9216-5413
2
Ipek Baysal
ORCID: 0000-0002-9607-4199
3
Salih Maçin
ORCID: 0000-0002-1871-3629
Anahtar Kelimeler
cystic echinococcosis
diagnostics
Echinococcus granulosus
microRNA
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey