Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
Fabad Journal of Pharmaceutical Sciences · Ağustos 2023
YÖKSİS Kayıtları
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
FABAD Farmasotik Bilimler Ankara Dernegi · 2023 SCOPUS
Prof. Dr. SALİH MAÇİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Intranasal Delivery of Nicotine Via Thermoresponsive Hydrogel Systems: Design, Characterization, And In Vitro Evaluation
2026 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Parasite-Derived MicroRNAs: Potential Alternative Targets for Laboratory Diagnosis of Cystic Echinococcosis
2023 ISSN: 1300-4182 SCOPUS
Prof. Dr. SALİH MAÇİN →
In vitro Evaluation of the Effects of Inula viscosa’s Different Extracts on Wound Healing and Oxidative Stress in Mouse L929 Fibroblast Cell Line
2024 ISSN: 1300-4182 scopus
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Development and Characterization of a Fixed-Dose Orodispersible Film of Telmisartan and Indapamide for Enhancing Dissolution
2025 ISSN: 1300-4182 TR DİZİN
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Makale Bilgileri
ISSN13004182
Yayın TarihiAğustos 2023
Cilt / Sayfa48 · 295-302
Scopus ID2-s2.0-85169542136
Erişim🔓 Açık Erişim
Özet
Cystic Echinococcosis (CE) is a type of zoonotic infection that can be caused by a specific form of a parasite called Echinococcus granulosus sensu lato. Mainly, imaging techniques are utilized to diagnose CE. Serological tests are only used when imaging findings are atypical. Additionally, laboratory assays including, direct microscopy and PCR are used to confirm of diagnosis after treatment though obtained negative results with these tests cannot be ruled out the diagnosis. Specific miRNAs produced by the parasite could be used as markers to diagnose and monitor CE. This research investigates the diagnostic potential of parasite-derived miRNAs compared to the presence of protoscolex in animal-derived hydatid cyst samples. Accordingly, egr-let-7-5p, egr-miR71-5p, and egr-miR-9-5p were positive in 26, 25, and 11 out of 30 samples (86.6%, 83.3%, and (36.6%), respectively. There was no relationship between protoscolex presence and detection of either egr-let-7-5p or egr-miR-9-5p (p>0.05). On the other hand, egr-miR71-5p positivity was found to be statistically significant compared with protoscolex presence (p=0.04). As a result, egr-miR-71 is a promising potential target for the diagnosis of CE. Additional research is necessary to assess the diagnostic value of miRNAs in CE using a larger group of samples.
Yazarlar (3)
1
Serra Örsten
ORCID: 0000-0002-9216-5413
2
Ipek Baysal
ORCID: 0000-0002-9607-4199
3
Salih Maçin
ORCID: 0000-0002-1871-3629
Anahtar Kelimeler
cystic echinococcosis
diagnostics
Echinococcus granulosus
microRNA
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fabad Journal of Pharmaceutical Sciences
Q3
SJR Skoru0,211
H-Index23
YayıncıSociety of Pharmaceutical Sciences of Ankara (FABAD)
ÜlkeTurkey
Pharmaceutical Science (Q3)