Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
Bioorganic Chemistry · Nisan 2025
YÖKSİS Kayıtları
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
Bioorganic Chemistry · 2025 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
Bioorganic Chemistry · 2025 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
Bioorganic Chemistry · 2025 SCI-Expanded
Doç. Dr. MEHMET OĞUZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix [4] arene l-proline derivatives
2020 ISSN: 0045-2068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Investigation of Inhibitory Properties of Some Hydrazone Compounds on hCA I, hCA II and AChE Enzymes
2019 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Antibacterial activities and DNA-cleavage properties of novel fluorescent imidazo-phenanthroline derivatives
2020 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. EMİNE ARSLAN →
Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors
2020 ISSN: 0045-2068 SCI-Expanded
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential
2020 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo IIα
2021 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi MUSTAFA KUL →
Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives
2022 ISSN: 0045-2068 SCI Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMET UYSAL →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Preparation of water-soluble imidazole-functionalized pillar[5]arenes: The activities of antibacterial and antioxidant, catalytic reduction of 4-nitrophenol
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA ÖZMEN →
Investigation of 2-substituted-5-methylsulfonylbenzoxazole derivatives as potential cholinesterase inhibitors: Synthesis, in vitro, and computational studies
2025 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Creative approaches for antibacterial, antioxidant and anticancer using honeycomb-type agents derived from a natural polymer
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMED NURİ KURŞUNLU →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
Dergi
Bioorganic Chemistry
ISSN00452068
Yayın TarihiNisan 2025
Cilt / Sayfa157
Scopus ID2-s2.0-85217956416
Özet
In this article, a series of calix[4]arenes derivatized with isatin derivatives at the phenolic-O position were synthesized as potential theranostic molecules for antitumor therapy. The cytotoxic mechanism of action of the synthesized compounds was determined by Alamar Blue assay and flow cytometry using MCF-7, MDA-MB-231, DLD1, HeLa and A549 human cancer cell lines and their ability to penetrate into PNT1A healthy epithelial cells. To detect DNA damage, the Comet test was applied after the synthesized compounds interacted with the cells. As a result, it was found that treated cells had abnormal tail nuclei and damaged DNA structures compared with untreated cells. Within the scope of enzyme inhibition experiments, studies were carried out on aromatase and COX-2 enzymes and it was determined that the compounds in the series showed inhibitory activity at varying rates. Especially compounds CLX-A3, CLX-A4, CLX-B3 and CLX-B5 attract attention with their enzyme inhibitor potential. Also, the antioxidant activities of the compounds whose synthesis was completed were also investigated and it was observed that the examined derivatives also had antioxidant activity potential. As a result of the antibacterial and antifungal test performed with broth microdilution, it was observed that the compounds had significant antibacterial and antifungal activity. The lowest MIC values were recorded as 0.006 mg/ml against Sarcina lutea and 0.048 against Candida albicans. In addition, the compound CLX-B3was observed to be effective against all strains including, Klebsiella pneumoniae and Salmonella enteritidis (Gram-negative pathogenic bacteria).
Yazarlar (5)
1
Alev Oguz
2
Ahmet Uysal
3
Begum Nurpelin Saglik Özkan
4
Mehmet Oguz
5
Mustafa Yilmaz
Anahtar Kelimeler
Anticancer
Antimicrobial
Aromatase inhibition
Calix[4]arene
Isatin
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Selcuk
Konya United States
Scimago Dergi (ISSN Eşleşmesi)
Bioorganic Chemistry
Q1
SJR Skoru0,786
H-Index95
YayıncıAcademic Press Inc.
ÜlkeUnited States
Organic Chemistry (Q1)
Biochemistry (Q2)
Drug Discovery (Q2)
Molecular Biology (Q3)
Metrikler
4
Atıf
5
Yazar
5
Anahtar Kelime