Scopus
YÖKSİS Eşleşti
Comparıson of the effect of the autogenıc and xenogenıc use of platelet-rıch plasma on rabbıt chondrocutaneous composıte graft survıval
Journal of Plastic Surgery and Hand Surgery · Ocak 2023
YÖKSİS Kayıtları
Comparison of the effect of the autogenic and xenogenic use of platelet-rich plasma on rabbit chondrocutaneous composite graft survival
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY · 2023 SCI
DOKTOR ÖĞRETİM ÜYESİ HANDE AKDENİZ →
Makale Bilgileri
DergiJournal of Plastic Surgery and Hand Surgery
Yayın TarihiOcak 2023
Cilt / Sayfa57 · 551-556
Scopus ID2-s2.0-85149053865
Özet
The platelet-rich plasma (PRP) has become popular in the medical world due to its content of growth factors and numerous studies are experimental. In experimental studies, the preparation and application of PRP are problematic and allogenic PRP transfers have been preffered, because of the difficulties in preparation of autogenic PRP in animal experiments. Xenogenic transfers and their effects have not been studied in this topic. This study aimed to investigate the effect of autogenic and xenogenic use of PRP on composite graft viability. Methods: Two composite grafts are prepared for each ear of nine rabbits. Each ear was randomly divided into three groups. After the procedure, the wound edges and base were injected with 1 cc serum physiologic, autogenic PRP or 1 cc human-derived xenogenic PRP. At 3 weeks, samples were taken, photographic and histopathological evaluations were made. Results: The graft viability was better in autogenic and xenogenic group compared to the control group. In comprasion of autogenic and xenogenic groups, although the macroscopic evaluation revealed better graft viability and less necrosis in the group which had been treated with autogenic PRP, the difference was not statistically significant. The three groups did not significantly differ in terms of inflammation. Vascularization examined histopathologically. CD31 staining, which was used to evaluate angiogenesis, was significantly higher in the autogenic PRP group than the remaining two groups. Conclusion: Although autogenic PRP has better results histopathologically, the xenogenic use of PRP may be an alternative for studies, when macroscopic evaluation is necessary.
Yazarlar (6)
1
Hande Akdeniz
2
Koray Gursoy
ORCID: 0000-0002-7730-7225
3
Gokay Baykara
ORCID: 0000-0001-6841-147X
4
Adile Dikmen
ORCID: 0000-0002-5601-1847
5
Hilal Ozakinci
ORCID: 0000-0001-7921-1000
6
Ugur Kocer
ORCID: 0000-0003-4245-0459
Anahtar Kelimeler
animal model
graft survival
Platelet rich-plasma
xenotransfusion
Kurumlar
Ankara Numune Education and Research Hospital
Ankara Turkey
Ankara Üniversitesi
Ankara Turkey
Sakarya Üniversitesi
Serdivan Turkey
Yüksek İhtisas Üniversitesi
Ankara Turkey