Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Acute necrotizing encephalopathy of childhood: A single-center experience
Turkish Journal of Medical Sciences · Ocak 2021
YÖKSİS Kayıtları
Acute necrotizing encephalopathy of childhood: a single-center experience
TURKISH JOURNAL OF MEDICAL SCIENCES · 2021 SCI-Expanded
Dr. Öğr. Üyesi FATİH MEHMET AKİF ÖZDEMİR →
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Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2021
Cilt / Sayfa51 · 706-715
Scopus ID2-s2.0-85105462251
Özet
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1-4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study.
Yazarlar (15)
1
Erhan Aksoy
2
Ülkühan Öztoprak
3
Halil Çelik
4
Fatih Mehmet Akif Özdemir
ORCID: 0000-0003-4820-1234
5
Mehpare Özkan
ORCID: 0000-0003-0896-8799
6
Hülya Kayalioğlu
ORCID: 0000-0001-7335-1985
7
Ayşegül Daniş
ORCID: 0000-0003-0962-2116
8
Özge Kucur
ORCID: 0000-0002-6597-4549
9
Selman Kesici
10
Mutlu Uysal Yazici
11
Ebru Azapağası
ORCID: 0000-0002-0684-8219
12
Yasemin Taşçi Yildiz
ORCID: 0000-0003-4639-2081
13
Nesrin Ceylan
ORCID: 0000-0001-5844-1261
14
Saliha Şenel
ORCID: 0000-0001-7203-5884
15
Deniz Yüksel
ORCID: 0000-0001-8990-023X
Anahtar Kelimeler
Childhood
Encephalopathy
Febrile illness
Multifocal brain lesions
Seizure(s)
Kurumlar
Abant Izzet Baysal University, Faculty of Medicine
Bolu Turkey
Hacettepe Üniversitesi
Ankara Turkey
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
University of Health Sciences
Istanbul Turkey
VM Medical Park Pendik Hospital
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
12
Atıf
15
Yazar
5
Anahtar Kelime