Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
Animals · Kasım 2022
YÖKSİS Kayıtları
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
PROFESÖR MAHMUT OK →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
DOÇENT MERVE İDER →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
Animals · 2022 SCI-Expanded
DOÇENT MEHMET BURAK ATEŞ →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
PROFESÖR FATİH HATİPOĞLU →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
MDPI AG · 2022 SCI-Expanded
PROFESÖR NURİ BAŞPINAR →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
PROFESÖR MUTLU SEVİNÇ →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
ANIMALS · 2022 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ SÜLEYMAN SERHAT İYİGÜN →
The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
MDPI AG · 2022 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ SÜLEYMAN SERHAT İYİGÜN →
Makale Bilgileri
DergiAnimals
Yayın TarihiKasım 2022
Cilt / Sayfa12
Scopus ID2-s2.0-85142421805
Erişim🔓 Açık Erişim
Özet
The purpose of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy and 25 calves with perinatal asphyxia were enrolled in the study. Clinical examination, neurological status score, and laboratory analysis were performed at admission, 24, 48, and 72 h. Serum concentrations of ubiquitin carboxy-terminal hydrolysis 1 (UCHL1), calcium-binding protein B (S100B), adrenomodullin (ADM), activitin A (ACTA), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and creatine kinase-brain (CK-B) were measured. Histopathological and immunohistochemical examinations of the brain tissue were performed in 13 nonsurvivor calves. The neurological status score of the calves with asphyxia was significantly (p < 0.05) lower. Mix metabolic-respiratory acidosis and hypoxemia were detected in calves with asphyxia. Serum UCHL1 and S100B were significantly (p < 0.05) increased, and NSE, ACTA, ADM, and CK-B were decreased (p < 0.05) in calves with asphyxia. Histopathological and immunohistochemical examinations confirmed the development of mild to severe hypoxic-ischemic encephalopathy. In conclusion, asphyxia and hypoxemia caused hypoxic-ischemic encephalopathy in perinatal calves. UCHL1 and S100B concentrations were found to be useful markers for the determination of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction.
Yazarlar (11)
1
M. Ok
2
Amir Naseri
3
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
4
Merve Ider
ORCID: 0000-0003-2928-5452
5
Kamil Üney
ORCID: 0000-0002-8674-4873
6
Mutlu Sevinc
7
Fatih Hatipoglu
8
Ramazan Yildiz
9
Alper Erturk
10
N. Baspinar
11
Suleyman Serhat Iyigun
Anahtar Kelimeler
brain damage
calf
mortality
perinatal asphyxia
serum biomarkers
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
11
Yazar
5
Anahtar Kelime