Scopus
YÖKSİS Eşleşti
mTOR inhibitors from a diagnostic perspective: radiolabeling of everolimus and its nanoformulation, in vitro incorporation assays against cervix and ovarian cancer cells
Journal of Radioanalytical and Nuclear Chemistry · Ocak 2022
YÖKSİS Kayıtları
mTOR inhibitors from a diagnostic perspective: radiolabeling of everolimus and its nanoformulation, in vitro incorporation assays against cervix and ovarian cancer cells
Journal of Radioanalytical and Nuclear Chemistry · 2022 SCI-Expanded
DOÇENT AHMET BİLGİ →
Makale Bilgileri
DergiJournal of Radioanalytical and Nuclear Chemistry
Yayın TarihiOcak 2022
Cilt / Sayfa331 · 171-178
Scopus ID2-s2.0-85118540207
Özet
mTOR inhibitors are recently important tools for cancer treatment. They act on cell growth regulation, proliferation, and survival. Pharmacological therapy with mTOR inhibitors such as everolimus is emerging as an alternate approach. Meanwhile, early diagnosis is a hot target in cancer research. Conversely, it can be a novel diagnosis approach to monitor mTOR inhibitors during their pathway. From this point of view, radiolabeling of everolimus and its nanoformulation (EVE-PLGA nanoparticles) in high yields (95%) with an important diagnostic radionuclide (technetium-99m) is described. Besides, in vitro incorporation assays of radiolabeled everolimus and its nanoformulation against the cervix and ovarian cancer cells were demonstrated 8- and 12-times high values than control group. In conclusion, radiolabeled everolimus and its nanoformulation have a promise to improve on monitoring mTOR inhibitors.
Yazarlar (9)
1
A. Bilgi
ORCID: 0000-0001-8682-1739
2
Ayfer Yurt Kilcar
ORCID: 0000-0003-0866-7515
3
Sevki Goksun Gokulu
ORCID: 0000-0002-6581-5716
4
Cansu Kayas
ORCID: 0000-0002-6030-3842
5
Nuri Yildirim
ORCID: 0000-0002-0605-4750
6
Kadriye Busra Karatay
ORCID: 0000-0002-2811-4689
7
Levent Akman
ORCID: 0000-0001-9399-8049
8
Fazilet Zumrut Biber Muftuler
ORCID: 0000-0001-8184-9660
9
Ahmet Aydin Ozsaran
Anahtar Kelimeler
Cervix and ovarian cancer cell lines
Everolimus (EVE)
mTOR inhibitor
Poly (lactic-co-glycolic acid) (PLGA)
SPECT tracer
Technetium-99 m ([ Tc]Tc) 99m
Kurumlar
Ege Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Mersin Üniversitesi
Mersin Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
1
Atıf
9
Yazar
6
Anahtar Kelime