Scopus
YÖKSİS Eşleşti
Is HPV-negative cervical carcinoma a different type of cervical cancer?
European Review for Medical and Pharmacological Sciences · Ocak 2023
YÖKSİS Kayıtları
Is HPV-negative cervical carcinoma a different type of cervical cancer?
Eur Rev Med Pharmacol Sci . · 2023 SCI
PROFESÖR MUSTAFA GAZİ UÇAR →
Makale Bilgileri
DergiEuropean Review for Medical and Pharmacological Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa27 · 9205-9212
Scopus ID2-s2.0-85174749949
Özet
– OBJECTIVE: Human papillomavirus (HPV), which is known to play a very important role in genital area (vulva, vagina, and cervix) cancers in women, is responsible for almost all cervical cancers. However, a significant proportion of cervical carcinomas (approximately 7%) is HPV-negative. Therefore, there are still two important questions to be answered: 1. Why is HPV Deoxyribonucleic acid (DNA) not found in all cervical carcinomas? 2. Are HPV-DNA-negative cervical cancers a specific subgroup of cervical cancers with different biological behavior (worse prognosis)? In this article, we aimed to evaluate the clinicopathological characteristics and survival of patients with confirmed HPV-negative tumors in order to answer these two questions. PATIENTS AND METHODS: A total of 97 patients who underwent HPV-DNA testing and received a histological diagnosis of cervical cancer were included in the study. 14 HPV-DNA negative and 83 HPV-DNA positive cervical carcinoma patients were detected. Demographic profiles, clinicopathological characteristics, progression-free, and overall survival of all patients were analyzed. RESULTS: Women with HPV-negative tumors were diagnosed at an older age range (p=0.05), and their demographic data other than age range were similar to HPV-positive tumors. P16 staining pattern was not observed in any of the HPV-negative tumors (p=0.001), and a positive P53 staining pattern was detected in 35.7% of the HPV-negative tumors. Although disease-free survival (PFS) (p=0.224) and overall survival (OS) (p=0.219) were worse in the HPV-negative patient group, this difference was not statistically significant. CONCLUSIONS: HPV-negative cervical cancers do not have a poor prognosis unlike their counterparts in other anatomical regions where HPV-associated tumors are present.
Yazarlar (6)
1
Mehmet Kulhan
ORCID: 0000-0002-5478-7510
2
A. Bilgi
ORCID: 0000-0001-8682-1739
3
Fazıl Avcı
ORCID: 0000-0002-9244-9168
4
Mustafa Gazi Uçar
5
C. Celik
ORCID: 0000-0002-9881-7814
6
Nur Gozde Kulhan
Anahtar Kelimeler
Cervical cancer
Cervical cancer subtypes
HPV-negative cervical cancers
Human papillomavirus
Prognosis
Kurumlar
Konya City Hospital
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
6
Yazar
5
Anahtar Kelime