Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation
Journal of Radioanalytical and Nuclear Chemistry · Şubat 2024
YÖKSİS Kayıtları
Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation
Journal of Radioanalytical and Nuclear Chemistry · 2024 SCI-Expanded
Doç. Dr. AHMET BİLGİ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells
2016 ISSN: 0236-5731 SCI-Expanded Q3
Doç. Dr. AHMET BİLGİ →
Investigation of nanoformulation and incorporation potential of radiolabeled curcumin using HeLa and MDAH-2774 cells
2021 ISSN: 0236-5731 SCI-Expanded Q3
Doç. Dr. AHMET BİLGİ →
mTOR inhibitors from a diagnostic perspective: radiolabeling of everolimus and its nanoformulation, in vitro incorporation assays against cervix and ovarian cancer cells
2022 ISSN: 0236-5731 SCI-Expanded Q3
Doç. Dr. AHMET BİLGİ →
Assessment of natural radioactivity level of soil and water in the region of Çorlu (Turkey)
2021 ISSN: 0236-5731 SCI-Expanded Q2
Prof. Dr. MEHMET ERDOĞAN →
Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation
2024 ISSN: 0236-5731 SCI-Expanded Q2
Doç. Dr. AHMET BİLGİ →
Investigation of radiological effects in surface soil samples taken from the surroundings of Konya Beyşehir Lake
2024 ISSN: 0236-5731 SSCI
Dr. Öğr. Üyesi HAMİDE AVCI →
Makale Bilgileri
ISSN02365731
Yayın TarihiŞubat 2024
Cilt / Sayfa333 · 665-672
Scopus ID2-s2.0-85182640297
Özet
Lapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(99mTc) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [99mTc]Tc-LPT and [99mTc]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer.
Yazarlar (9)
1
Sevki Goksun Gokulu
ORCID: 0000-0002-6581-5716
2
Kadriye Busra Karatay
ORCID: 0000-0002-2811-4689
3
A. Bilgi
ORCID: 0000-0001-8682-1739
4
Cansu Kayas
ORCID: 0000-0002-6030-3842
5
Nuri Yildirim
ORCID: 0000-0002-0605-4750
6
Ayfer Yurt Kilcar
ORCID: 0000-0003-0866-7515
7
Fazilet Zumrut Biber Muftuler
ORCID: 0000-0001-8184-9660
8
Mustafa Cosan Terek
ORCID: 0000-0002-0294-2857
9
Levent Akman
ORCID: 0000-0001-9399-8049
Anahtar Kelimeler
Cervix adenocarcinoma (HeLa)
Human breast adenocarcinoma (MDA-MB-231)
Human ovarian (MDAH-2774)
Lapatinib (LPT)
Poly(lactic-co-glycolic acid) (PLGA)
Technetium-99 m ( Tc) 99m
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Ege Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Mersin Üniversitesi
Mersin Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Radioanalytical and Nuclear Chemistry
Q3
SJR Skoru0,354
H-Index81
YayıncıSpringer Nature
ÜlkeSwitzerland
Analytical Chemistry (Q3)
Health, Toxicology and Mutagenesis (Q3)
Nuclear Energy and Engineering (Q3)
Pollution (Q3)
Public Health, Environmental and Occupational Health (Q3)
Radiology, Nuclear Medicine and Imaging (Q3)
Spectroscopy (Q3)
Metrikler
1
Atıf
9
Yazar
6
Anahtar Kelime