Scopus
YÖKSİS Eşleşti
Synthesis and in vitro evaluation of <sup>99m</sup>Tc radiolabeled lapatinib (LPT) and its PLGA formulation
Journal of Radioanalytical and Nuclear Chemistry · Şubat 2024
YÖKSİS Kayıtları
Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation
Journal of Radioanalytical and Nuclear Chemistry · 2024 SCI-Expanded
DOÇENT AHMET BİLGİ →
Makale Bilgileri
DergiJournal of Radioanalytical and Nuclear Chemistry
Yayın TarihiŞubat 2024
Cilt / Sayfa333 · 665-672
Scopus ID2-s2.0-85182640297
Özet
Lapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(99mTc) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [99mTc]Tc-LPT and [99mTc]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer.
Yazarlar (9)
1
Sevki Goksun Gokulu
ORCID: 0000-0002-6581-5716
2
Kadriye Busra Karatay
ORCID: 0000-0002-2811-4689
3
A. Bilgi
ORCID: 0000-0001-8682-1739
4
Cansu Kayas
ORCID: 0000-0002-6030-3842
5
Nuri Yildirim
ORCID: 0000-0002-0605-4750
6
Ayfer Yurt Kilcar
ORCID: 0000-0003-0866-7515
7
Fazilet Zumrut Biber Muftuler
ORCID: 0000-0001-8184-9660
8
Mustafa Cosan Terek
ORCID: 0000-0002-0294-2857
9
Levent Akman
ORCID: 0000-0001-9399-8049
Anahtar Kelimeler
Cervix adenocarcinoma (HeLa)
Human breast adenocarcinoma (MDA-MB-231)
Human ovarian (MDAH-2774)
Lapatinib (LPT)
Poly(lactic-co-glycolic acid) (PLGA)
Technetium-99 m ( Tc) 99m
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Ege Üniversitesi
Izmir Turkey
Ege University Medical School
Izmir Turkey
Mersin Üniversitesi
Mersin Turkey
Selçuk Tip Fakültesi
Konya Turkey