Scopus
Effects of oriental sweet gum storax on porcinewound healing
Journal of Investigative Surgery · Ağustos 2012
Makale Bilgileri
DergiJournal of Investigative Surgery
Yayın TarihiAğustos 2012
Cilt / Sayfa25 · 262-270
Scopus ID2-s2.0-84864595252
Özet
Purpose: The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model. Methods: Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 × 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured. Results: In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups. Conclusion: The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects. © 2012 Informa Healthcare USA, Inc.
Yazarlar (6)
1
Hakan Ocsel
2
Zafer Teke
3
Mustafa Saçar
4
Burhan Kabay
5
S. Ender Duzcan
6
Inci Kara
Anahtar Kelimeler
Granulation tissue
Hydrocolloid dressing
Liquidambar orientalis Mill
Oriental sweet gum
Re-epithelialization
Silver sulfadiazine
Storax
Styrax
Wound healing
Kurumlar
Çanakkale Onsekiz Mart Üniversitesi
Canakkale Turkey
Pamukkale Üniversitesi
Denizli Turkey
Turkey Yuksek Ihtisas Teaching and Research Hospital
Denizli Turkey
Metrikler
15
Atıf
6
Yazar
9
Anahtar Kelime