Scopus
YÖKSİS Eşleşti
Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes
Research on Chemical Intermediates · Şubat 2021
YÖKSİS Kayıtları
Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes
Research on Chemical Intermediates · 2021 SCI-Expanded
PROFESÖR ZAFER SAYIN →
Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes
Research on Chemical Intermediates · 2021 SCI-Expanded
PROFESÖR ÜLKÜ AKPINAR →
Makale Bilgileri
DergiResearch on Chemical Intermediates
Yayın TarihiŞubat 2021
Cilt / Sayfa47 · 533-550
Scopus ID2-s2.0-85092231648
Özet
Metal complexes of thiosemicarbazones have been receiving considerable attention in biological applications such as antimicrobial and anticancer therapies. In this work, Co(II), Zn(II) and Mn(II) complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) were synthesized for the first time and characterized by EPR, FT-IR, NMR, UV–Vis spectroscopies, TG/DSC and elemental analysis. X-ray powder diffraction analysis was carried out for Zn(II) complex. HMAT and its Cu(II), Co(II), Zn(II) and Mn(II) complexes were tested as enzyme inhibitory agents. All compounds are effective inhibitor of cytosolic carbonic anhydrase I and II isoforms (hCA I and II) enzymes. IC50 values of HMAT and its Cu(II), Co(II), Zn(II) and Mn(II) complexes were determined as 93.35, 324.46, 25.67, 1.06 and 22.36 μM for CA I isozyme and 99.02, 86.64, 57.76, 10.34 and 36.48 μM for CA II isozyme, respectively. The evaluation of potential cytotoxic effects of the compounds was performed against normal epithelial breast mammary gland CRL-4010, estrogen-positive low metastatic MCF-7 and triple negative highly metastatic MDA-MB-231 breast adenocarcinoma cell lines by MTT assay. The results showed that the tested metal complexes have high cytotoxic effects than their ligand molecule. In particular, the Cu(II) complex displayed preciously high cytotoxic properties different from the others. Given these facts, the Cu(II) complex could be debated as potential chemotherapeutic molecule against drug-resistant breast cancer cells. Minimum inhibitory concentrations of the compounds against the test organisms were also detected for the microbiological analysis.
Yazarlar (7)
1
Asuman Ucar
2
Mukerrem Findik
3
Muslum Kuzu
4
Suray Pehlivanoglu
5
Ulku Sayin
6
Zafer Sayın
7
Emine Guler Akgemci
Anahtar Kelimeler
Antimicrobial and anticancer activity
Carbonic anhydrase
Complexes
Spectroscopic and thermal analysis
Thiosemicarbazone
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Karabük Üniversitesi
Karabuk Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
7
Yazar
5
Anahtar Kelime