Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Evaluation of Boron’s Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · Mart 2021
YÖKSİS Kayıtları
Evaluation of Borons Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Evaluation of Boron's Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
BIOLOGICAL TRACE ELEMENT RESEARCH · 2021 SCI-Expanded
Prof. Dr. ZAFER SAYIN →
Evaluation of Boron's Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Evaluation of Boron\u2019s Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Investigation of the Relationship Between Serum Trace Elements and MSFC Levels in Multiple Sclerosis: A Cross-sectional Case-Control Study
2025 ISSN: 0163-4984 SCI
Dr. Öğr. Üyesi CİHAT ÖZGÜNCÜ →
Effects of Zinc Deficiency and Supplementation on Malondialdehyde and Glutathione Levels in Blood and Tissues of Rats Performing Swimming Exercise
2003 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effect of Selenium Supplementation on Lipid Peroxidation Antioxidant Enzymes and Lactate Levels in Rats Immediately After Acute Swimming Exercise
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effects of dietary cadmium and boron supplementation on performance eggshell quality and mineral concentrations of bone in laying hens
2015 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. OSMAN OLGUN →
Serum and Cerebrospinal Fluid Magnesium Levels Glasgow Coma Scores and In Hospital Mortality in Patients with Acute Stroke
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Magnesium Sulfate in Emergency Department Patients with Hypertension
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Levels of Selenium Zinc Copper and Cardiac Troponin I in Serum of Patients with Acute Coronary Syndrome
2013 ISSN: 0163-4984 SSCI
Prof. Dr. HASAN KARA →
Elements in Sera of Elite Taekwondo Athletes Effects of Vitamin E Supplementation
2011 ISSN: 0163-4984 SCI 3 atıf
Prof. Dr. EKREM BOYALI →
The Effect of Vitamin A Supplementation on Various Elements in Elite Taekwondo Players
2011 ISSN: 0163-4984 SCI 2 atıf
Prof. Dr. EKREM BOYALI →
Effects of Exercise and Zinc Supplementation on Cytokine Release in Young Wrestlers
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Intraperitoneal Selenium Administration on Liver Glycogen Levels in Rats Subjected to Acute Forced Swimming
2011 ISSN: 0163-4984 SSCI
Prof. Dr. MEHMET KILIÇ →
Effects of Acute Swimming Exercise on Some Elements in Rats
2009 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effects of Chronic Fluorosis on Electrocardiogram in Sheep
2003 ISSN: 0163-4984 SCI-Expanded 24 atıf
Prof. Dr. NURCAN DÖNMEZ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded 10 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Testosterone Levels in Athletes at Rest and Exhaustion Effects of Calcium Supplementation
2009 ISSN: 0163-4984 SCI-Expanded 3 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion
2011 ISSN: 0163-4984 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissue of rats performing swimming exercise
2003 ISSN: 0163-4984 SCI-Expanded 18 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effects of exercise and zinc supplementation on cytokine release in young wrestlers
2011 ISSN: 0163-4984 SSCI 4 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc supplementation on the element distribution in kidney tissue of diabetic rats subjected to acute swimming
2012 ISSN: 0163-4984 SSCI 5 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Makale Bilgileri
ISSN01634984
Yayın TarihiMart 2021
Cilt / Sayfa199 · 1037-1043
Scopus ID2-s2.0-85086734846
Özet
Vaccination is the most effective, reliable, and economical way of preventing or reducing the effect of infectious diseases. When preparing inactive vaccines, a range of additives called adjuvants are necessary to enhance the magnitude of the immune response. Boron has a wide range of industrial and medical applications, and its positive effects on distinct functions have been described in plants, humans, and animals. However, no studies exist about the possible adjuvant activities of boron compounds in vaccines. Hence, in this study, the potential adjuvant effect of boric acid was explored and compared with common veterinary adjuvants in a mice model. Staphylococcus aureus (S. aureus) used as vaccine antigen was isolated from dairy cows with bovine mastitis. Vaccines adjuvanted with boric acid, aluminum hydroxide, Montanide ISA 50 and ISA 206, and Montanide + boric acid combinations were prepared. The efficacy of vaccines was evaluated according to local reactions at the injection site, C-reactive protein, total Ig G, total Ig M, and anti-S. aureus antibody levels in mice. Boric acid reduced local inflammatory reactions induced by the Montanide adjuvants. Moreover, mice vaccinated with boric acid-adjuvanted vaccine had higher levels of anti-S. aureus antibody than those in the controls (P < 0.05) and were similar to the levels found in mice sensitized with aluminum hydroxide. Total Ig G and Ig M results were, however, unsuitable for the assessment of adjuvant activity for this study. In conclusion, this study revealed that boric acid has an adjuvant potential in inactive bacterin vaccines, but further target animal studies are needed.
Yazarlar (8)
1
Zafer Sayın
2
Ali Uslu
3
O. Erganiş
4
Abdullah Başoğlu
5
O. Ozdemir
6
Aslı Sakmanoğlu
7
Uçkun Sait Uçan
8
Zeki Aras
Anahtar Kelimeler
Adjuvant
Aluminum hydroxide
Boric acid
Montanide ISA 206
Montanide ISA 50
Vaccine
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biological Trace Element Research
Q1
OA
SJR Skoru0,890
H-Index119
YayıncıSpringer
ÜlkeUnited States
Inorganic Chemistry (Q1)
Biochemistry (Q2)
Biochemistry (medical) (Q2)
Clinical Biochemistry (Q2)
Endocrinology, Diabetes and Metabolism (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
5
Atıf
8
Yazar
6
Anahtar Kelime