Scopus
YÖKSİS Eşleşti
Do specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
Brain, Behavior, and Immunity · Şubat 2025
YÖKSİS Kayıtları
Do specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
Brain, Behavior, and Immunity · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSTAFA ESAD TEZCAN →
Do specific myelin autoantibodies and increased cerebral dopamine
neurotrophic factor in the context of inflammation predict the diagnosis of
attention deficit hyperactivity disorder in medication-free children?
Brain Behavior and Immunity · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ FATİH EKİCİ →
Makale Bilgileri
DergiBrain, Behavior, and Immunity
Yayın TarihiŞubat 2025
Cilt / Sayfa124 · 125-136
Scopus ID2-s2.0-85210761017
Özet
Background: The aim of this study was to investigate the serum levels of anti-myelin basic protein (anti-MBP), anti-myelin oligodentrocyte glycoprotein (anti-MOG), myelin-associated glycoprotein (MAG), high-sensitivity C-reactive protein (hs-CRP), cerebral dopamine neurotrophic factor (CDNF), cerebellin-1, and reelin and their relationships with clinical severity and irritability behaviours in children with attention deficit (AD) hyperactivity disorder (ADHD) and typically developing (TD) healthy controls. Methods: In this study, 141 children with ADHD between the ages of 8 and 14 years who were medication-free and 135 TD healthy controls were included. The serum levels of anti-MBP, anti-MOG, MAG, CDNF, hs-CRP, cerebellin, and reelin were measured using enzyme-linked immunosorbent assay kits. The Turgay Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-based Screening and Evaluation Scale for Attention Deficit and Disruptive Behavior Disorders–Parent Form (TDSM-IV-O) and the affective reactivity index (ARI) scale were used to assess clinical severity and irritability behaviours in the children. Results: The MAG, CDNF, hs-CRP, reelin, and cerebellin levels were significantly higher in the ADHD group than in the control group, but no significant differences in anti-MBP and anti-MOG levels were found between the groups. Compared with the controls, the patients with ADHD showed significantly higher scores on the ARI self- and parent-report scales. The reelin, hs-CRP, and MAG levels were significantly associated with the TDSM-IV-O AD scores, AD and oppositional defiant (OD) disorder scores and hyperactivity, and OD and conduct disorder scores, respectively. Hs-CRP was significantly associated with anti-MBP and cerebellin levels. In an analysis of covariance, the results were unchanged even after controlling for potential confounders such as age, body mass index, and sex. Conclusion: This study demonstrates that MAG, CDNF, hs-CRP, reelin, and cerebellin levels may play a potential role in the pathogenesis of ADHD.
Yazarlar (12)
1
Mustafa Esad Tezcan
ORCID: 0000-0001-8362-1934
2
Fatih Ekici
ORCID: 0000-0003-4000-7429
3
Cuneyt Ugur
4
Ümmügülsüm Can
5
Serdar Karatoprak
6
Gökçeçiçek Arıcı Sağlıyan
7
Ekrem Furkan Uçak
8
Ahmet Güleç
ORCID: 0000-0001-9979-5891
9
Vefa Erbasan
10
Barış Şen
ORCID: 0000-0002-3902-1816
11
Fulya Simsek
12
Abdullah Enes Atas
Anahtar Kelimeler
Attention deficit hyperactivity disorder
Cerebellin-1
Cerebral dopamine neurotrophic factor
Child
High sensitivity c-reactive protein
Inflammation
Myelin antibodies
Myelin associated glycoprotein
Reelin
Kurumlar
Balıkesir Atatürk City Hospital
Balikesir Turkey
Izmir City Hospital
Izmir Türkiye
Konya City Hospital
Karatay/Konya Turkey
Manavgat State Hospital
Manavgat-Antalya Turkey
University of Health Sciences
Istanbul Turkey