Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Regional distribution of genetic mutation in lung cancer in Turkey (Redigma)
Tuberkuloz ve Toraks · Ocak 2019
YÖKSİS Kayıtları
Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA).
Tüberküloz ve Toraks · 2019 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ ATİLLA CAN →
Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX · 2019 Emerging Sources Citation Index
DOKTOR ÖĞRETİM ÜYESİ ATİLLA CAN →
Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)
Tüberküloz ve Toraks · 2019 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ ATİLLA CAN →
Makale Bilgileri
DergiTuberkuloz ve Toraks
Yayın TarihiOcak 2019
Cilt / Sayfa67 · 197-204
Scopus ID2-s2.0-85074742012
Erişim🔓 Açık Erişim
Özet
Introduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey. Materials and Methods: Regional distribution of genetic mutations in lung cancer in Turkey (REDIGMA) study was carried out as a prospective, cross-sectional, observational study in a large number of centers in which lung cancer patients were followed and could perform genetic mutation analysis on patients’ biopsy materials. Results: The 703 patients (77.7% male, mean age 63.3 ± 12.5 years) who were diagnosed as NSCLC from 25 different centers were included in the study. Tumor samples from patients were reported as 87.1% adenocarcinoma, 6.4% squamous cell carcinoma and 6.5% other. Mutation tests were found to be positive in 18.9% of these patients. The mutations were 69.9% EGFR, 26.3% ALK, 1.6% ROS and 2.2% PDL. Mutations were higher in women and non-smokers (p< 0.000, p< 0.001). Again, the frequency of mutations in adenocarcinoma was higher in metastatic disease. There was no difference between the patient’s age, area of residence, comorbidity and clinical stage and mutation frequency. Conclusion: Our study revealed that the EGFR mutation rate in Turkey with NSCLC was similar to East European, African–American and Caucasian patients, and was lower than in East Asia.
Yazarlar (30)
1
Neslihan Özçelik
ORCID: 0000-0002-4672-6179
2
Nimet Aksel
ORCID: 0000-0001-8725-3323
3
Yılmaz Bülbül
4
Yurdanur Erdoğan
5
Filiz Güldaval
6
Şule Karabulut Gül
7
Ahmet Bircan
8
Atilla Can
ORCID: 0000-0002-9603-2861
9
Necdet Öz
10
Ayşegül Şentürk
11
Sibel Arinç
12
Talat Kiliç
13
Emine Bahar Kurt
14
Ersin Günay
15
Benan Çağlayan
16
Derya Çelebi Aydin
17
İlknur Başyiğit
18
İsmail Savaş
19
Dursun Tatar
ORCID: 0000-0002-6285-3549
20
Sulhattin Arslan
21
Berna Kömürcüoğlu
22
Mehmet Bayram
23
İnci Gülmez
24
Ömer Tamer Doğan
25
Elif Yelda Özgün Niksarlioğlu
26
Erkan Kaba
27
Selen Karaoğlanoğlu
28
Esra Aydin Özgür
29
Ali Erdem Özçelik
30
Tevfik Özlü
Anahtar Kelimeler
ALK
Carsinoma
EGFR
Non-small cell lung cancer
Regional distribution
Turkey
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Ankara Üniversitesi
Ankara Turkey
Atatürk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara
Ankara Turkey
Balikesir Chest Diseases Hospital
Balikesir Turkey
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Demiroglu Bilim University
Istanbul Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital
Izmir Türkiye
Erciyes Üniversitesi
Kayseri Turkey
Inönü Üniversitesi
Malatya Turkey
Karadeniz Technical University
Trabzon Turkey
Kartal Dr. Lütfi Kırdar City Hospital
Istanbul Türkiye
Kocaeli Üniversitesi
İzmit Turkey
Koç Üniversitesi
Istanbul Turkey
Konya Meram Training and Research Hospital
Konya Turkey
Memorial and Medstar Oncology Center
Antalya Turkey
Ordu Üniversitesi
Ordu Turkey
Recep Tayyip Erdogan University
Rize Turkey
Süleyman Demirel University, Faculty of Medicine
Isparta Turkey
Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital
Istanbul Turkey
Yedikule Chest Diseases and Chest Surgery Training and Research Hospital
Istanbul Türkiye
Metrikler
5
Atıf
30
Yazar
6
Anahtar Kelime