Scopus
YÖKSİS Eşleşti
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic and Histochemistry · Mayıs 2018
YÖKSİS Kayıtları
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic Histochemistry · 2018 SCI
PROFESÖR TUĞBA ÖZAYDIN →
Effects of Bisphenol A on Antioxidant System and Lipid Profile in Rats
Biotechnic Histochemistry SCI-Expanded
PROFESÖR TUĞBA ÖZAYDIN →
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic Histochemistry · 2018 SCI
PROFESÖR EMRAH SUR →
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic Histochemistry · 2018 SCI-Expanded
PROFESÖR MUSTAFA ORHUN DAYAN →
Effects of bisphenol A on antioxidant system and lipid profile in rats
BIOTECHNIC & HISTOCHEMISTRY · 2018 SCI
PROFESÖR İLHAMİ ÇELİK →
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic Histochemistry · 2018 SCI-Expanded
PROFESÖR İLHAMİ ÇELİK →
Effects of bisphenol A on antioxidant system and lipid profile in rats
Biotechnic Histochemistry · 2018 SCI
PROFESÖR YASEMİN ÖZNURLU →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiMayıs 2018
Cilt / Sayfa93 · 231-238
Scopus ID2-s2.0-85041612754
Özet
We investigated the effects of bisphenol A (BPA) on antioxidant system enzymes, blood lipid profile and histologic structure of liver and pancreas in rats. We used 40 8-week-old male Wistar albino rats. The animals were divided into five groups of eight: control, vehicle, BPA-5, BPA-50 and BPA-500. BPA was dissolved in ethanol, then mixed with corn oil. The control group was untreated. The vehicle group was given the ethanol-corn oil mixture. The BPA 5, BPA 50 and BPA 500 groups were given 5, 50, and 500 µg/kg body weights/day, respectively. After 8 weeks, blood and tissue samples were obtained from the animals and plasma GSH, TBARS, SOD, GPx, CAT, NO, total cholesterol, triglyceride, HDL, LDL, insulin and glucose were measured. The sections were stained using histochemical and immunohistochemical methods. BPA significantly decreased the levels of GSH, SOD, GPx and CAT, and increased the levels of TBARS and NO in plasma. There was no significant difference among the groups in plasma insulin and glucose levels. The percentage of insulin immunoreactive cells in islets increased significantly in the BPA-500 group. The H-score of the BPA-5 and BPA-50 groups decreased significantly compared to controls. We found that BPA caused oxidative stress and disruption of pancreatic β-cell function. Therefore, BPA is a risk factor for animal and human health.
Yazarlar (6)
1
Tuǧba Özaydin
2
Yasemin Öznurlu
3
Emrah Sur
4
Ilhami Çelik
5
Deniz Uluíşik
6
M. O. Dayan
Anahtar Kelimeler
Antioxidant
bisphenol A
lipid
liver
pancreas
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
30
Atıf
6
Yazar
5
Anahtar Kelime