Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Assessing safety and efficacy of TNFi treatment in late onset ankylosing spondylitis: a TURKBIO registry study
Scientific Reports · Aralık 2024
YÖKSİS Kayıtları
Assessing Safety and Efficacy of TNFi Treatment in Late Onset Ankylosing Spondylitis: A TURKBIO Registry Study
Scientific Reports · 2024 SCI-Expanded
PROFESÖR SEMA YILMAZ →
Makale Bilgileri
DergiScientific Reports
Yayın TarihiAralık 2024
Cilt / Sayfa14
Scopus ID2-s2.0-85196393883
Erişim🔓 Açık Erişim
Özet
Clinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with the initial use of TNFi therapy in biologic naive patients diagnosed with LoAS. Patients whose age of onset was ≥ 45 years and < 45 years were classified as having LoAS and YoAS, respectively, based on the age of symptom onset. There were 2573 patients with YoAS and 281 LoAS. Baseline disease activity measures were similar between the groups. No significant differences were seen between the two groups in response to treatment and in remaining on the first TNFi at 6, 12 and 24 months. In the LoAS group, the analysis showed that TNFi discontinuation was linked to VAS pain score (HR 1.04; 95% CI 1.01–1.06). Patient groups had similar rates of adverse events (YoAS: 8.7% vs. LoAS: 11.7%). In both biologic naive LoAS and YoAS patients, the study showed that the initial TNFi therapy was equally effective and safe.
Yazarlar (20)
1
Sadettin Uslu
ORCID: 0000-0001-6266-2454
2
Semih Gulle
ORCID: 0000-0001-8679-2130
3
Gercek Sen
ORCID: 0000-0001-8347-0873
4
Ayse Cefle
ORCID: 0000-0002-3273-7969
5
Sema Yılmaz
ORCID: 0000-0003-4277-3880
6
Sinem Burcu Kocaer
ORCID: 0000-0002-5481-0776
7
Tuba Yuce Inel
ORCID: 0000-0001-9026-9641
8
Suleyman Serdar Koca
ORCID: 0000-0003-4995-430X
9
Servet Yolbas
ORCID: 0000-0001-8516-9769
10
Mehmet Akif Öztürk
11
Soner Senel
ORCID: 0000-0002-1523-0066
12
Nevsun Inanc
ORCID: 0000-0003-2862-0562
13
Huseyin Ediz Dalkilic
ORCID: 0000-0001-8645-2670
14
Ozgul Soysal Gunduz
ORCID: 0000-0002-8149-9311
15
Abdurrahman Tufan
ORCID: 0000-0001-6244-9362
16
Servet Akar
ORCID: 0000-0002-3734-1242
17
Ahmet Merih Birlik
ORCID: 0000-0001-5118-9307
18
Ismail Sari
ORCID: 0000-0001-7737-4180
19
Nurullah Akkoc
ORCID: 0000-0002-3718-171X
20
Fatos Onen
ORCID: 0000-0002-6341-2622
Anahtar Kelimeler
45 years
Ankylosing spondylitis
Late-onset ankylosing spondylitis
TNFi
TURKBIO
Kurumlar
Batman Training and Research Hospital
Batman Türkiye
Bursa Uludağ Üniversitesi
Bursa Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Erciyes University, Faculty of Medicine
Kayseri Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
Izmir Ekonomi Üniversitesi
Izmir Turkey
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kocaeli Üniversitesi
İzmit Turkey
Manisa Celâl Bayar Üniversitesi
Manisa Turkey
Marmara Üniversitesi Tip Fakültesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
3
Atıf
20
Yazar
5
Anahtar Kelime