Scopus
YÖKSİS Eşleşti
The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken
Birth Defects Research · Eylül 2021
YÖKSİS Kayıtları
The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken
Birth Defects Research · 2021 SCI-Expanded
PROFESÖR TUĞBA ÖZAYDIN →
The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken
Birth Defects Research · 2021 SCI-Expanded
PROFESÖR EMRAH SUR →
The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken
Birth Defects Research · 2021 SCI-Expanded
PROFESÖR YASEMİN ÖZNURLU →
The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken
Birth Defects Research · 2021 SCI-Expanded
PROFESÖR HALUK ÖZPARLAK →
Makale Bilgileri
DergiBirth Defects Research
Yayın TarihiEylül 2021
Cilt / Sayfa113 · 1130-1139
Scopus ID2-s2.0-85105914628
Özet
Objectives: The aim of this study was to determine of the effects of in ovo administered BPA on embryonic development of the tibial growth plate using histological methods in chickens. Methods: Three hundred and ten fertile eggs of Isa Brown laying parent stock were divided into five groups as untreated control, vehicle-injected control, 50, 100, and 250 μg/egg BPA. At the 13th, 18th, and 21st days of incubation, eggs were randomly opened from each group until 10 live embryos were obtained. Embryos were weighed and crown-rump length was measured. Tibial tissue samples were taken from embryos. Tibia weight, relative tibia weight and tibia length were determined. Tissue samples were fixed in 10% buffered formalin solution. Sections were stained with Safranin O staining methods and zones in the growth plate were measured. Also, proliferating cell nuclear antigen (PCNA) was stained immunohistochemically. Results: The mortality in the BPA treated groups was higher than untreated control group. The results have revealed that mean relative embryo weights, crown-rump length, mean tibia weight, relative tibia weight, and tibia length of BPA treated groups were significantly lower when compared to the untreated control and vehicle-injected control groups. Also, proliferative zone get significantly narrowed, whereas the transitional and hypertrophic zone thickened and PCNA positive chondrocytes increased in growth plate of BPA treated groups. Conclusion: These results have suggested that developmental exposure to BPA adversely affected development of the tibial growth plate.
Yazarlar (4)
1
Yasemin Öznurlu
2
Tuǧba Özaydin
3
Emrah Sur
4
Haluk Ozparlak
Anahtar Kelimeler
Bisphenol A
chicken
histomorphometry
PCNA
tibial growth plate
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
4
Yazar
5
Anahtar Kelime