Scopus
YÖKSİS Eşleşti
The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: A single-blind, randomised study
Human Psychopharmacology · Ocak 2011
YÖKSİS Kayıtları
The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor refractory obsessive compulsive disorder a single blind randomised study
Human Psychopharmacology: Clinical and Experimental · 2011 SSCI 31 atıf
PROFESÖR YAVUZ SELVİ →
Makale Bilgileri
DergiHuman Psychopharmacology
Yayın TarihiOcak 2011
Cilt / Sayfa26 · 51-57
Scopus ID2-s2.0-79953245254
Özet
Objective: To investigate the comparative efficacy of aripiprazole and risperidone as augmenting agents in the treatment of obsessive-compulsive disorder (OCD) patients who did not show a ≥35% decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) after 12-week monotherapy with selective serotonin reuptake inhibitors (SSRIs). Methods: The study consists of two different periods of treatment: a 12-week prospective period to determine resistance to SSRI treatment and an 8-week single-blind addition period for refractory patients only. Ninety patients were randomly assigned to receive one of the SSRI treatments. Sixty-nine patients (76.6%) completed the 12-week SSRI monotherapy period. Forty-one patients (59.4%) were considered refractory and were randomised to receive either risperidone (20 patients, 3 mgr daily) or aripiprazole (21 patients, 15 mgr daily) as augmentation to SSRI treatment. Sixteen patients (76.2%) in the aripiprazole group and 18 patients (84%) in the risperidone group completed the 8-week treatment period. Results: Eight patients (50%) in aripiprazole and 13 patients (72.2%) in risperidone group met response criteria of Y-BOCS decrease ≥35% at the end of the study. The risperidone group showed a significant improvement in Y-BOCS obsession scores compared with aripiprazole. Conclusions The present findings suggest that risperidone may be more effective than aripiprazole. Copyright © 2011 John Wiley & Sons, Ltd.
Yazarlar (6)
1
Yavuz Selvi
2
Abdullah Atli
3
Adem Aydin
4
Lutfullah Besiroglu
5
Pinar Guzel Ozdemir
6
Osman Ozdemir
Anahtar Kelimeler
Antipsychotic
Obsessive-compulsive disorder
Treatment-refractory
Kurumlar
Van Yüzüncü Yıl Üniversitesi
Van Turkey
Metrikler
48
Atıf
6
Yazar
3
Anahtar Kelime