Scopus
YÖKSİS Eşleşti
The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions
Acta Psychiatrica Scandinavica · Ağustos 2011
YÖKSİS Kayıtları
The involvement of distinct neural systems in patients with obsessive compulsive disorder with autogenous and reactive obsessions
Acta Psychiatrica Scandinavica · 2011 SSCI 20 atıf
PROFESÖR YAVUZ SELVİ →
Makale Bilgileri
DergiActa Psychiatrica Scandinavica
Yayın TarihiAğustos 2011
Cilt / Sayfa124 · 141-151
Scopus ID2-s2.0-79960198245
Özet
Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions. Method: We assessed right anterior cingulate cortex (ACC) and amygdala-hippocampal region (Am+Hpp) N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single-voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD-A), 15 patients with reactive obsessions (OCD-R) and 15 healthy controls (HC). Measurements were repeated after 16weeks of fluoxetine treatment. Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD-A group had significantly lower baseline NAA/Cr ratios in the Am+Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD-A group found in the Am+Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios. Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions. © 2011 John Wiley & Sons A/S.
Yazarlar (9)
1
Lutfullah Besiroglu
2
M. Sozen
3
Ozgur Ozbebit
4
S. Avcu
5
Yavuz Selvi
6
A. Bora
7
Abdullah Atli
8
Ö Ünal
9
M. D. Bulut
Anahtar Kelimeler
Limbic system
Magnetic resonance spectroscopy
Obsessive-compulsive disorder
Serotonin specific reuptake inhibitors
Subtypes
Kurumlar
Ipekyolu State Hospital
Van Turkey
Van Yüzüncü Yıl Üniversitesi
Van Turkey
Metrikler
29
Atıf
9
Yazar
5
Anahtar Kelime