Scopus
YÖKSİS Eşleşti
Decreased miR-15b-5p/miR-155-5p levels and increased imiR-134-5p/miR-652-3p levels among BD patients under lithium treatment
Journal of Affective Disorders · Kasım 2022
YÖKSİS Kayıtları
Decreased miR-15b-5p/miR-155-5p levels and increased miR-134-5p/miR-652-3p levels among BD patients under lithium treatment
JOURNAL OF AFFECTIVE DISORDERS · 2022 SSCI
DOKTOR ÖĞRETİM ÜYESİ RUKİYE TEKDEMİR →
Decreased miR-15b-5p/miR-155-5p levels and increased miR-134-5p/miR-652-3p levels among BD patients under lithium treatment
JOURNAL OF AFFECTIVE DISORDERS · 2022 SSCI
PROFESÖR YAVUZ SELVİ →
Makale Bilgileri
DergiJournal of Affective Disorders
Yayın TarihiKasım 2022
Cilt / Sayfa317 · 6-14
Scopus ID2-s2.0-85136517869
Özet
Background: There is an increasing interest about the role of miRNAs in the pathogenesis of bipolar disorder (BD). In this study, we aimed to examine the role of miRNAs as potential diagnostic and clinical biomarkers in BD. Methods: Fifteen miRNAs in plasmas obtained from BD patients (n = 66) and from the healthy control group (n = 66) were analyzed by a qPCR test. Clinical variables including lithium treatment response were assessed with various test batteries. The correlation of the miRNA levels with the clinical variables and scale scores was examined. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using the DIANA-miRPath v.3.0 software to identify the possible target genes. Results: The miR-132, miR-134, miR-152, miR-607, miR-633, and miR-652 levels were significantly increased, whereas the miR-15b and miR-155 levels were found to be significantly decreased in the patient group compared to the controls. The miR-15b-5p and miR-155-5p levels and increases in the miR-134-5p and miR-652-3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD. miR-155-5p was associated with the disease burden and severity. Fatty acid biosynthesis and metabolism, viral carcinogenesis, the EBV infection, and extracellular matrix and adhesion pathways were highlighted as target pathways. Conclusion: We can conclude that miRNAs may play a role in the pathophysiology of BD through various biological pathways and that miRNAs may be used as a screening test to distinguish bipolar patients from healthy controls. Our findings will provide a basis for long-term follow-up studies with larger samples.
Yazarlar (4)
1
Rukiye Tekdemir
ORCID: 0000-0001-7912-5727
2
Yavuz Selvi
3
Kürşat Altınbaş
4
Nadir Koçak
ORCID: 0000-0002-1104-1292
Anahtar Kelimeler
Biomarker
Bipolar disorder
Circadian rhythm
Lithium response
MicroRNA
Kurumlar
Ankara Ataturk Research and Training Hospital
Ankara Türkiye
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
7
Atıf
4
Yazar
5
Anahtar Kelime