Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Lower morning levels of cortisol and neuropeptides in blood samples from patients with bipolar disorder
Journal of Affective Disorders Reports · Aralık 2022
YÖKSİS Kayıtları
Lower morning levels of cortisol and neuropeptides in blood samples from patients with bipolar disorder
Journal of Affective Disorders Reports · 2022 Scopus Directory of Open Access Journals (DOAJ)
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Makale Bilgileri
DergiJournal of Affective Disorders Reports
Yayın TarihiAralık 2022
Cilt / Sayfa10
Scopus ID2-s2.0-85136476668
Erişim🔓 Açık Erişim
Özet
Background: Several lines of evidence indicate that circadian rhythm disruption is associated with bipolar disorder (BPD). This strong association, along with evidence from genome wide association studies (GWAS) implicating clock and clock controlled genes with BDP and efficacy of lithium treatment, suggests that BPD circadian rhythm disruption may represent a core etiology feature. Lower morning expression of the neuropeptide somatostatin (SST) has been previously reported in the brain and cerebral spinal fluid of subjects with BPD, coinciding with increased morning severity of anxiety and depression. We aimed to test the hypothesis that levels of neuropeptides involved in circadian rhythm regulation, including somatostatin (SST), neuropeptide-Y (NPY), arginine vasopressin (AVP), vasoactive intestinal peptide (VIP) and cortisol levels, are altered in blood samples collected in the morning from patients BPD. Method: Thirty nine patients diagnosed as BPD according to DSM-5, and 38 healthy controls were enrolled in the study. Blood were collected at 9 AM from all subjects. Serum levels of SST, NPY, AVP, VIP and cortisol were measured. Results: We observed significantly lower levels of SST (p = 0.001), NPY (p = 0.001), VIP (p = 0.001) and cortisol levels (p = 0.001) in the morning in subjects with BPD compared to control subjects. Significant positive effects of Young Mania Rating Scale and lithium treatment with cortisol, SST, and VIP levels were observed. Conclusion: Our study suggests that lower morning levels of SST, NPY, VIP and cortisol may represent biomarkers underlying disrupted biological rhythms and behavioral and sleep disturbances observed in patients with BPD.
Yazarlar (13)
1
Emrah Yildiz
2
Gulcin Elboga
ORCID: 0000-0003-3903-1835
3
Merve Cıkılı Uygun
4
Rabia Yilmaz
5
Yavuz Selvi
6
Hasan Ulusal
ORCID: 0000-0003-3890-2088
7
Esra Çelik
8
Musa Sahpolat
ORCID: 0000-0002-0022-2389
9
Zeynep Zehra Yildiz
10
Onur Hursitoglu
11
Abdurrahman Altindag
ORCID: 0000-0001-5531-4419
12
Mehmet Tarakçioglu
13
Harry Pantazopoulos
ORCID: 0000-0002-8905-8377
Anahtar Kelimeler
Anxiety
Anxiety/anxiety disorders
Bipolar disorder
Circadian rhythm
Depression
Neuropeptide
Sleep disorders
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Kilis State Hospital
Kilis Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Sular Academy Hospital
Kahramanmaras Turkey
T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi
Mersin Turkey
University of Mississippi Medical Center
Jackson United States