Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Clinical features and outcome of MIS-C patients: an experience from Central Anatolia
Clinical Rheumatology · Ekim 2021
YÖKSİS Kayıtları
Clinical features and outcome of MIS-C patients: an experience from Central Anatolia
CLINICAL RHEUMATOLOGY · 2021 SCI
DOÇENT MELİKE EMİROĞLU →
Clinical features and outcome of MIS-C patients: an experience from Central Anatolia
Clinical Rheumatology · 2021 SCI-Expanded
PROFESÖR AHMET SERT →
Makale Bilgileri
DergiClinical Rheumatology
Yayın TarihiEkim 2021
Cilt / Sayfa40 · 4179-4189
Scopus ID2-s2.0-85105531875
Erişim🔓 Açık Erişim
Özet
Background: Multisystem inflammatory syndrome in children (MIS-C) is a new clinical condition characterized by signs of inflammation and multiorgan dysfunction due to cytokine storm associated with SARS-CoV-2. The clinical spectrum of MIS-C ranges from mild to severe, and even to mortal multisystem involvement. To guide clinicians, we evaluated detailed demographic characteristics, clinical features, laboratory findings, and outcomes of MIS-C cases. Methods: We performed a retrospective study of patients with MIS-C who were managed in the Department of Pediatric Infectious Disease in the Selcuk University Faculty of Medicine, Konya, Turkey. MIS-C patients were divided into three clinical severity groups (mild, moderate, and severe) and separated into three age groups (< 5 years, 5–10 years, > 10 years). We compared the characteristics of MIS-C cases according to the severity of the disease and by age groups. Result: Thirty-six children with MIS-C were evaluated (52.8% male, median age of 7.8 years). A clinical spectrum overlapping with Kawasaki disease (KD) was the most common presentation (69.4%) in all age groups. The most common clinical symptoms were fever (100%), mucocutaneous rash (69.4%), and gastrointestinal symptoms (66.6%). There was no statistically significant difference in echocardiographic abnormality between KD-like and the other clinical spectra (p > 0.05). All life-threatening rhythm disturbances were observed in severe cases. No patients died. Conclusion: It is important to increase the awareness of physicians about the MIS-C disease, which can present with different combinations of different systemic findings, so that patients can be diagnosed and treated in a timely manner.Key Points• A single tertiary centre study shows that children with MIS-C can present with different clinic spectra other than Kawasaki diseases.• Electrocardiographic and echocardiographic evaluation is important in early diagnosis of children with MIS-C.• Pro-BNP can be used as a screening test in the emergency room for children with prolonged and unexplained fever for determine early cardiac involvement of MIS-C.• The lack of require biological agents and favourable outcomes in children with MIS-C may be related with administration of steroid therapy with IVIG in early stage of disease.
Yazarlar (5)
1
Gulsum Alkan
ORCID: 0000-0003-3384-769X
2
Ahmet Sert
ORCID: 0000-0002-1607-7569
3
Sadiye Kubra Tuter Oz
ORCID: 0000-0002-2473-5672
4
Melike Emiroglu
ORCID: 0000-0003-1307-0246
5
Resul Yilmaz
Anahtar Kelimeler
Cardiac involvement
Multisystem inflammatory syndrome in children
Outcomes
Symptoms
Treatment
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
27
Atıf
5
Yazar
5
Anahtar Kelime