Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · Ocak 2024
YÖKSİS Kayıtları
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
Arş. Gör. BUSE KAVAKLI →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
Doç. Dr. DURMUŞ HATİPOĞLU →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
The Pakistan Veterinary Journal · 2024 SCI-Expanded
Prof. Dr. BURAK DİK →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
Doç. Dr. MEHMET BURAK ATEŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses
2015 ISSN: 0253-8318 SSCI
Prof. Dr. MUSTAFA ARICAN →
Bacillus anthracis isolated from a dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
A Retrospective Study of Fractures in Neonatal Calves 181 Cases 2002 2012
2013 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The investigation of bovine viral diarrhoea virus antigens with immunofluorescence and immunohistochemical methods in bovine abortions
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of different storage temperatures on the stability of bovine viral diarrhea virus RNA in blood samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ATİLLA ŞİMŞEK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. SİBEL YAVRU →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and PetDogs
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
Quantification of mitral regurgitation in Anatolian Shepherd Dogs with aseymtomatic degenerative mitral valve disease
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and Pet Dogs
2016 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
In Vitro Activity of Toxin Binders on Aflatoxin B1 in Poultry Gastrointestinal Medium
2018 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling
and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. MUSTAFA ORHUN DAYAN →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q1
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN02538318
Yayın TarihiOcak 2024
Cilt / Sayfa44 · 931-937
Scopus ID2-s2.0-85207267870
Erişim🔓 Açık Erişim
Özet
The aim of our study was to investigate the potential effects of alpha-lipoic acid (ALA) and resatorvid (RES) on gentamicin-induced hepatotoxicity. Thirty-four rats were divided into the following groups: Healthy control (n=6), Gentamicin (GNT, 80 mg/kg, n=7), GNT + Sham (10% hydroalcoholic solution, n=7), GNT + RES (5 mg/kg, n=7), and GNT + ALA (100 mg/kg, n=7). In the GNT group, a statistically significant increase in ALT levels and a significant decrease in total protein (TP) and albumin (TA) levels were observed compared to the control group. On the other hand, a significant increase in NRF-2, NF-κB, NR4A2 and CAS-3 expression was detected in the GNT group as compared to the control group. Simultaneous administration of RES or ALA with GNT led to a significant decrease in ALT levels compared to the GNT group. In addition, these treatments caused a significant increase in TP and TA levels. RES administration caused a significant decrease in gene expression compared to the GNT group. On the other hand, simultaneous ALA treatment with GNT caused a significant decrease in NRF-2, CAS-3 and NF-κB expression and partially reduced NR4A2 expression. These findings draw attention to the potential of RES or ALA to alleviate gentamicin-induced hepatotoxicity and to their increased efficacy in the treatment of infections.
Yazarlar (5)
1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
3
Aysegul Bulut
4
Buse Gezgic
5
Burak Dik
Anahtar Kelimeler
Alpha Lipoic Acid
Gentamicin
Hepatotoxicity
NRF2
Resatorvid
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pakistan Veterinary Journal
Q1
OA
SJR Skoru0,845
H-Index44
YayıncıUniversity of Agriculture
ÜlkePakistan
Veterinary (miscellaneous) (Q1)
Metrikler
13
Atıf
5
Yazar
5
Anahtar Kelime